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  1. Primary Research

    The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells

    Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid,...

    Ling-Yun Ye, Song Hu, Hua-E Xu, Rong-Rong Xu, Hui Kong, Xiao-Ning Zeng, Wei-Ping Xie and Hong Wang

    Cancer Cell International 2017 17:40

    Published on: 27 March 2017

  2. Primary research

    rs35301225 polymorphism in miR-34a promotes development of human colon cancer by deregulation of 3′UTR in E2F1 in Chinese population

    Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cell cycle-related transcriptional factor E2F1. To date, the function of t...

    Haiqiang Jiang, Fengyuan Ge, Beina Hu, Lamei Wu, Huijian Yang and Huiyun Wang

    Cancer Cell International 2017 17:39

    Published on: 9 March 2017

  3. Primary Research

    miR-484 suppresses proliferation and epithelial–mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells

    MicroRNAs (miRNAs) play important roles in cancer initiation and development. Epithelial–mesenchymal transition (EMT) is a form of cellular plasticity that is critical for embryonic development and metastasis....

    Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu and Hua Tang

    Cancer Cell International 2017 17:36

    Published on: 7 March 2017

  4. Primary research

    HLBT-100: a highly potent anti-cancer flavanone from Tillandsia recurvata (L.) L.

    The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, ef...

    Henry I. C. Lowe, Ngeh J. Toyang, Charah T. Watson, Kenneth N. Ayeah and Joseph Bryant

    Cancer Cell International 2017 17:38

    Published on: 7 March 2017

  5. Primary research

    Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

    2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ thr...

    Yao Fong, Chang-Yi Wu, Kuo-Feng Chang, Bing-Hung Chen, Wan-Ju Chou, Chih-Hua Tseng, Yen-Chun Chen, Hui-Min David Wang, Yeh-Long Chen and Chien-Chih Chiu

    Cancer Cell International 2017 17:37

    Published on: 7 March 2017

  6. Primary research

    Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

    Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers including leukemia. LEE011 is a novel inhibitor of both CDK4 and 6. To date, the molecular function of L...

    Yan-Fang Tao, Na-Na Wang, Li-Xiao Xu, Zhi-Heng Li, Xiao-Lu Li, Yun-Yun Xu, Fang Fang, Mei Li, Guang-Hui Qian, Yan-Hong Li, Yi-Ping Li, Yi Wu, Jun-Li Ren, Wei-Wei Du, Jun Lu, Xing Feng…

    Cancer Cell International 2017 17:35

    Published on: 6 March 2017

  7. Primary research

    Transactivation of the estrogen receptor promoter by BRCA1

    Absence of the estrogen receptor-α (ER) is perhaps the most distinctive pathological feature of breast cancers arising in women who inherit a mutation in BRCA1. Two hypotheses, not necessarily mutually exclusi...

    William B. Archey and Bradley A. Arrick

    Cancer Cell International 2017 17:33

    Published on: 2 March 2017

  8. Primary Research

    Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma

    G protein–coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with patholo...

    Shuli Liu, Dongxia Ye, Tong Wang, Wenzheng Guo, Hongyong Song, Yueling Liao, Dongliang Xu, Hanguang Zhu, Zhiyuan Zhang and Jiong Deng

    Cancer Cell International 2017 17:34

    Published on: 2 March 2017

  9. Primary research

    Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells

    Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism...

    Norlaily Mohd Ali, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Huynh Ky, Ahmad Zaim Mat Pauzi, Wan Yong Ho, Sheau Wei Tan, Han Kiat Alan-Ong, Seema Zareen, Noorjahan Banu Alitheen and M. Nadeem Akhtar

    Cancer Cell International 2017 17:30

    Published on: 21 February 2017

  10. Hypothesis

    The heterogeneity of cancer stem-like cells at the invasive front

    Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid...

    Go J. Yoshida

    Cancer Cell International 2017 17:23

    Published on: 13 February 2017

  11. Primary research

    Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma

    Increased expression of suppressor of zest 12 (SUZ12), a core component of the polycomb repressive complex 2, contributes to human tumorigenesis and associates with patient prognosis. In the present study, we ...

    Huijun Hu, Yi Wang, Zhongwu Li, Yumin Zhu, Wei Zhang, Dongmiao Wang, Tangyi Lin, Jianrong Yang, Yanling Wang and Jie Cheng

    Cancer Cell International 2017 17:26

    Published on: 13 February 2017

  12. Primary research

    Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand

    Glioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with ste...

    Se-Jeong Oh, Jung-In Yang, Ok Kim, Eun-Jung Ahn, Woo Dae Kang, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee and Duck Cho

    Cancer Cell International 2017 17:22

    Published on: 10 February 2017

  13. Review

    Paradoxes of the EphB1 receptor in malignant brain tumors

    Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ep...

    Wenqiang Wei, Hongju Wang and Shaoping Ji

    Cancer Cell International 2017 17:21

    Published on: 8 February 2017

  14. Primary research

    Effect of RAGE gene polymorphisms and circulating sRAGE levels on susceptibility to gastric cancer: a case–control study

    To investigate the influence of polymorphisms in the receptor for advanced glycation end products (RAGE) gene and circulating soluble RAGE (sRAGE) levels on susceptibility to gastric cancer, and identify wheth...

    Taijie Li, Weijuan Qin, Yanqiong Liu, Shan Li, Xue Qin and Zhiming Liu

    Cancer Cell International 2017 17:19

    Published on: 6 February 2017

  15. Primary research

    The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147

    Recently, miR-22 is identified as a tumor-suppressing microRNA in many human cancers. CD147 is a novel cancer-associated biomarker that plays an important role in the invasion and metastasis of malignant tumor...

    Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti and Yan Lin

    Cancer Cell International 2017 17:17

    Published on: 2 February 2017

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