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  1. Primary Research

    Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma

    G protein–coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with patholo...

    Shuli Liu, Dongxia Ye, Tong Wang, Wenzheng Guo, Hongyong Song, Yueling Liao, Dongliang Xu, Hanguang Zhu, Zhiyuan Zhang and Jiong Deng

    Cancer Cell International 2017 17:34

    Published on: 2 March 2017

  2. Primary research

    Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells

    Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism...

    Norlaily Mohd Ali, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Huynh Ky, Ahmad Zaim Mat Pauzi, Wan Yong Ho, Sheau Wei Tan, Han Kiat Alan-Ong, Seema Zareen, Noorjahan Banu Alitheen and M. Nadeem Akhtar

    Cancer Cell International 2017 17:30

    Published on: 21 February 2017

  3. Hypothesis

    The heterogeneity of cancer stem-like cells at the invasive front

    Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid...

    Go J. Yoshida

    Cancer Cell International 2017 17:23

    Published on: 13 February 2017

  4. Primary research

    Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma

    Increased expression of suppressor of zest 12 (SUZ12), a core component of the polycomb repressive complex 2, contributes to human tumorigenesis and associates with patient prognosis. In the present study, we ...

    Huijun Hu, Yi Wang, Zhongwu Li, Yumin Zhu, Wei Zhang, Dongmiao Wang, Tangyi Lin, Jianrong Yang, Yanling Wang and Jie Cheng

    Cancer Cell International 2017 17:26

    Published on: 13 February 2017

  5. Primary research

    Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand

    Glioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with ste...

    Se-Jeong Oh, Jung-In Yang, Ok Kim, Eun-Jung Ahn, Woo Dae Kang, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee and Duck Cho

    Cancer Cell International 2017 17:22

    Published on: 10 February 2017

  6. Review

    Paradoxes of the EphB1 receptor in malignant brain tumors

    Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ep...

    Wenqiang Wei, Hongju Wang and Shaoping Ji

    Cancer Cell International 2017 17:21

    Published on: 8 February 2017

  7. Primary research

    Effect of RAGE gene polymorphisms and circulating sRAGE levels on susceptibility to gastric cancer: a case–control study

    To investigate the influence of polymorphisms in the receptor for advanced glycation end products (RAGE) gene and circulating soluble RAGE (sRAGE) levels on susceptibility to gastric cancer, and identify wheth...

    Taijie Li, Weijuan Qin, Yanqiong Liu, Shan Li, Xue Qin and Zhiming Liu

    Cancer Cell International 2017 17:19

    Published on: 6 February 2017

  8. Primary research

    The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147

    Recently, miR-22 is identified as a tumor-suppressing microRNA in many human cancers. CD147 is a novel cancer-associated biomarker that plays an important role in the invasion and metastasis of malignant tumor...

    Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti and Yan Lin

    Cancer Cell International 2017 17:17

    Published on: 2 February 2017

  9. Primary research

    Global expression profile of tumor stem-like cells isolated from MMQ rat prolactinoma cell

    Cancer stem cells (CSCs), which have been isolated from various malignancies, were closely correlated with the occurrence, progression, metastasis and recurrence of the malignant cancer. Little is known about ...

    Zhipeng Su, Lin Cai, Jianglong Lu, Chuzhong Li, Songbai Gui, Chunhui Liu, Chengde Wang, Qun Li, Qichuan Zhuge and Yazhuo Zhang

    Cancer Cell International 2017 17:15

    Published on: 31 January 2017

  10. Primary research

    MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7

    MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigat...

    Wei Xia, JueYu Zhou, HaiBo Luo, YunZhou Liu, CanCan Peng, WenLing Zheng and WenLi Ma

    Cancer Cell International 2017 17:14

    Published on: 25 January 2017

  11. Primary research

    TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells

    Despite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment. Therefore, finding ways to reduce the toxicity and increase sensitivity is particula...

    Xiao Wu, Meng-Yao Wu, Min Jiang, Qiaoming Zhi, Xiaojie Bian, Meng-Dan Xu, Fei-Ran Gong, Juan Hou, Min Tao, Liu-Mei Shou, Weiming Duan, Kai Chen, Meng Shen and Wei Li

    Cancer Cell International 2017 17:13

    Published on: 23 January 2017

  12. Primary Research

    HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway

    Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition and invasion and metastasis capacities. However, its ...

    Shengjie Dai, Jie Zhang, Shihao Huang, Bin Lou, Binbo Fang, Tingting Ye, Xince Huang, Bicheng Chen and Mengtao Zhou

    Cancer Cell International 2017 17:12

    Published on: 10 January 2017

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