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  1. Primary research

    Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand

    Glioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with ste...

    Se-Jeong Oh, Jung-In Yang, Ok Kim, Eun-Jung Ahn, Woo Dae Kang, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee and Duck Cho

    Cancer Cell International 2017 17:22

    Published on: 10 February 2017

  2. Review

    Paradoxes of the EphB1 receptor in malignant brain tumors

    Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ep...

    Wenqiang Wei, Hongju Wang and Shaoping Ji

    Cancer Cell International 2017 17:21

    Published on: 8 February 2017

  3. Primary research

    Effect of RAGE gene polymorphisms and circulating sRAGE levels on susceptibility to gastric cancer: a case–control study

    To investigate the influence of polymorphisms in the receptor for advanced glycation end products (RAGE) gene and circulating soluble RAGE (sRAGE) levels on susceptibility to gastric cancer, and identify wheth...

    Taijie Li, Weijuan Qin, Yanqiong Liu, Shan Li, Xue Qin and Zhiming Liu

    Cancer Cell International 2017 17:19

    Published on: 6 February 2017

  4. Primary research

    The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147

    Recently, miR-22 is identified as a tumor-suppressing microRNA in many human cancers. CD147 is a novel cancer-associated biomarker that plays an important role in the invasion and metastasis of malignant tumor...

    Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti and Yan Lin

    Cancer Cell International 2017 17:17

    Published on: 2 February 2017

  5. Primary research

    Global expression profile of tumor stem-like cells isolated from MMQ rat prolactinoma cell

    Cancer stem cells (CSCs), which have been isolated from various malignancies, were closely correlated with the occurrence, progression, metastasis and recurrence of the malignant cancer. Little is known about ...

    Zhipeng Su, Lin Cai, Jianglong Lu, Chuzhong Li, Songbai Gui, Chunhui Liu, Chengde Wang, Qun Li, Qichuan Zhuge and Yazhuo Zhang

    Cancer Cell International 2017 17:15

    Published on: 31 January 2017

  6. Primary research

    MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7

    MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigat...

    Wei Xia, JueYu Zhou, HaiBo Luo, YunZhou Liu, CanCan Peng, WenLing Zheng and WenLi Ma

    Cancer Cell International 2017 17:14

    Published on: 25 January 2017

  7. Primary research

    TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells

    Despite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment. Therefore, finding ways to reduce the toxicity and increase sensitivity is particula...

    Xiao Wu, Meng-Yao Wu, Min Jiang, Qiaoming Zhi, Xiaojie Bian, Meng-Dan Xu, Fei-Ran Gong, Juan Hou, Min Tao, Liu-Mei Shou, Weiming Duan, Kai Chen, Meng Shen and Wei Li

    Cancer Cell International 2017 17:13

    Published on: 23 January 2017

  8. Primary Research

    HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway

    Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition and invasion and metastasis capacities. However, its ...

    Shengjie Dai, Jie Zhang, Shihao Huang, Bin Lou, Binbo Fang, Tingting Ye, Xince Huang, Bicheng Chen and Mengtao Zhou

    Cancer Cell International 2017 17:12

    Published on: 10 January 2017

  9. Primary research

    Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells

    Casticin, the flavonoid extracted from Vitex rotundifolia L, exerts various biological effects, including anti-inflammatory and anti-cancer activity. The aim of this study is to investigate the effects and mechan...

    Xiao-ling Song, Yun-jiao Zhang, Xue-feng Wang, Wen-jie Zhang, Zheng Wang, Fei Zhang, Yi-jian Zhang, Jian-hua Lu, Jia-wei Mei, Yun-ping Hu, Lei Chen, Huai-feng Li, Yuan-yuan Ye, Ying-bin Liu and Jun Gu

    Cancer Cell International 2017 17:9

    Published on: 5 January 2017

  10. Primary research

    Circulating tumor microemboli (CTM) and vimentin+ circulating tumor cells (CTCs) detected by a size-based platform predict worse prognosis in advanced colorectal cancer patients during chemotherapy

    Circulating tumor cells (CTCs) detected in peripheral blood (PB) of cancer patients can be identified as isolated CTCs and circulating tumor microemboli (CTM). This study aimed to evaluate the prognostic value...

    Dejun Zhang, Lei Zhao, Pengfei Zhou, Hong Ma, Fang Huang, Min Jin, Xiaomeng Dai, Xiumei Zheng, Shaoyi Huang and Tao Zhang

    Cancer Cell International 2017 17:6

    Published on: 5 January 2017

  11. Primary Research

    Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro

    Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients’ mortality is metastasis. At the start of metastasis progression, there is an epith...

    Virginia Andrea Angiolini, Carolina Uribe Cruz, Mónica Luján López, Laura Simon and Ursula Matte

    Cancer Cell International 2017 17:5

    Published on: 4 January 2017

  12. Primary research

    miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma

    Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck with strong ability of invasion and metastasis. Our previous study indicated that miR-324-3p, as a tumor-suppressive fact...

    Chao Liu, Guo Li, Nianting Yang, Zhongwu Su, Shuiting Zhang, Tengbo Deng, Shuling Ren, Shanhong Lu, Yongquan Tian, Yong Liu and Yuanzheng Qiu

    Cancer Cell International 2017 17:2

    Published on: 3 January 2017

  13. Primary Research

    Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)

    Betulinic acid and betulin are triterpenes that have anticancer properties in various types of cancer. Unfortunately, the bioavailability and the bio-distribution of betulinic acid and its metabolic precursor,...

    Małgorzata Drąg-Zalesińska, Marcin Drąg, Marcin Poręba, Sylwia Borska, Julita Kulbacka and Jolanta Saczko

    Cancer Cell International 2017 17:4

    Published on: 3 January 2017

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