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  1. Review

    HOTAIR: a key regulator in gynecologic cancers

    Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can inter...

    Jing Li, Jing Wang, Yan Zhong, Ruixia Guo, Danxia Chu, Haifeng Qiu and Zhongfu Yuan

    Cancer Cell International 2017 17:65

    Published on: 21 June 2017

  2. Primary Research

    Overexpression of lncRNA HOXA11-AS promotes cell epithelial–mesenchymal transition by repressing miR-200b in non-small cell lung cancer

    Recent studies have verified that long noncoding RNAs (lncRNAs) involved in many biological functions and play crucial roles in human cancers progression, the study aimed to detect the association between long...

    Jian-Hui Chen, Li-Yang Zhou, Suo Xu, Yu-Long Zheng, Yu-Feng Wan and Cheng-Ping Hu

    Cancer Cell International 2017 17:64

    Published on: 12 June 2017

  3. Primary Research

    Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA

    To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes.

    Quanfeng Wu, Xiaoli Wu, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu and Xipeng Wang

    Cancer Cell International 2017 17:62

    Published on: 6 June 2017

  4. Primary Research

    Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines

    Hepatocellular carcinoma (HCC) is the seventh most common malignancy and the third leading cause of cancer-related death worldwide with an extremely grim prognosis. Berberine (BBR) has been found to inhibit pr...

    Tung-Yueh Chuang, Hsiao-Li Wu, Jie Min, Michael Diamond, Ricardo Azziz and Yen-Hao Chen

    Cancer Cell International 2017 17:59

    Published on: 30 May 2017

  5. Review

    Pepsinogen C expression, regulation and its relationship with cancer

    Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions ...

    Shixuan Shen, Jingyi Jiang and Yuan Yuan

    Cancer Cell International 2017 17:57

    Published on: 23 May 2017

  6. Research article

    DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification

    The DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy, a fatal progressive muscle wasting disease. DMD has also been shown to act as a tumor suppressor gene. Rhabdomyosarcoma (RMS) is a mesod...

    Emma Tabe Eko Niba, Ryo Yamanaka, Abdul Qawee Mahyoob Rani, Hiroyuki Awano, Masaaki Matsumoto, Hisahide Nishio and Masafumi Matsuo

    Cancer Cell International 2017 17:58

    Published on: 23 May 2017

  7. Primary Research

    Growth of MCF-7 breast cancer cells and efficacy of anti-angiogenic agents in a hydroxyethyl chitosan/glycidyl methacrylate hydrogel

    Breast cancer negatively affects women’s health worldwide. The tumour microenvironment plays a critical role in tumour initiation, proliferation, and metastasis. Cancer cells are traditionally grown in two-dim...

    Hejing Wang, Junmin Qian, Yaping Zhang, Weijun Xu, Juxiang Xiao and Aili Suo

    Cancer Cell International 2017 17:55

    Published on: 16 May 2017

  8. Primary Research

    Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation

    Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Mor...

    Feifei Xu, Jialu Zhang, Guolin Hu, Lei Liu and Weijiang Liang

    Cancer Cell International 2017 17:54

    Published on: 12 May 2017

  9. Primary Research

    The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells

    For every six men, one will be diagnosed with prostate cancer (PCa) in their lifetime. Estrogen receptors (ERs) are known to play a role in prostate carcinogenesis. However, it is unclear whether the estrogeni...

    Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D. P. Hammer, Bin Guo and Othman Ghribi

    Cancer Cell International 2017 17:52

    Published on: 11 May 2017

  10. Primary Research

    Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study

    Oral reactive lesions are the most common lesions of oral cavity. Phospholipases and fatty acids play key roles in the creation of inflammation by change in metabolic activities and production of lipid mediato...

    Ali Hossein Mesgarzadeh, Abolfazl Akbarzadeh, Ali Rasipour, Tannaz Rasipour, Amir Mehdizadeh and Maghsod Shaaker

    Cancer Cell International 2017 17:50

    Published on: 27 April 2017

  11. Primary Research

    pATM and γH2AX are effective radiation biomarkers in assessing the radiosensitivity of 12C6+ in human tumor cells

    Tumour radiosensitivity would be particularly useful in optimizing the radiation dose during radiotherapy. The aim of the current study was to evaluate the potential value of phosphorylated H2AX (γH2AX) and AT...

    Jin Zhao, Zhong Guo, Shuyan Pei, Lei Song, Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, Ying Ma and Hong Zhang

    Cancer Cell International 2017 17:49

    Published on: 26 April 2017

  12. Primary Research

    Metformin exhibits the anti-proliferation and anti-invasion effects in hepatocellular carcinoma cells after insufficient radiofrequency ablation

    The mechanisms and prevention of progression of hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA) has been preliminarily investigated, therefore, new strategy needs to be investig...

    Qingyun Zhang, Jian Kong, Shuying Dong, Wenlei Xu and Wenbing Sun

    Cancer Cell International 2017 17:48

    Published on: 24 April 2017

  13. Primary Research

    Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients

    Pancreatic ductal adenocarcinomas are among the most malignant neoplasms and have very poor prognosis. Our understanding of various cancers has recently improved the survival of patients with cancer, except fo...

    Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim and Seung-Mo Hong

    Cancer Cell International 2017 17:47

    Published on: 20 April 2017

  14. Primary Research

    MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2

    Lung cancer is the major cause of cancer-related death worldwide, and 80% patients of lung cancer are non-small-cell lung cancer (NSCLC) cases. MicroRNAs are important gene regulators with critical roles in di...

    Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo and Guoqiang Zhao

    Cancer Cell International 2017 17:46

    Published on: 17 April 2017

  15. Primary Research

    MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

    MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); howev...

    Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin and Xiao-Li Ma

    Cancer Cell International 2017 17:43

    Published on: 31 March 2017

  16. Primary Research

    The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines

    Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as non-small-cell lung cancer (NSCLC) and cisplatin rem...

    Stéfano M. Cirigliano, María I. Díaz Bessone, Damián E. Berardi, Carolina Flumian, Elisa D. Bal de Kier Joffé, Silvio E. Perea, Hernán G. Farina, Laura B. Todaro and Alejandro J. Urtreger

    Cancer Cell International 2017 17:42

    Published on: 31 March 2017

  17. Primary Research

    Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma

    Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulate...

    Shilpa Bhatia, Kellen Hirsch, Sanjana Bukkapatnam, Nimrah A. Baig, Ayman Oweida, Anastacia Griego, Dylan Calame, Jaspreet Sharma, Andrew Donson, Nicholas Foreman, Christopher Albanese, Sujatha Venkataraman, Rajeev Vibhakar and Sana D. Karam

    Cancer Cell International 2017 17:41

    Published on: 29 March 2017

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