Role of arginine and its methylated derivatives in cancer biology and treatment

Table 1 Effect of D-Arg, L-Arg and DL-Arg on the growth of transplantable animal tumours

Treatment	Tumour	Number of animals		Daily dose (mg/kg)	Duration of treatment (days)	Inhibition %	Remarks
		Treated	Control
D-Arg ¹	Yoshida	6	6	500 p.o.	12	50	p < 0.05
D-Arg ¹	Ehrlich s.c.	10	10	500 i.p.	10	20	p < 0.1
L-Arg³	Yoshida	10	10	400 i.p.	10	-40	Enhancement p < 0.05
L-Arg³	Yoshida	10	10	400 p.o.	9	-30	Enhancement p < 0.1
L-Arg²	Ehrlich s.c.	10	10	500 i.p.	12	-40	Enhancement p < 0.05
DL-Arg³	Ehrlich s.c.	10	10	500 i.p.	12	-	-

¹Serva (USA), ²Ajinomoto (Japan), ³Reanal (Hungary) Animals were sacrificed 24 hours after the last treatment and tumour weight was measured. Inhibition or enhancement is given as per cent of the control tumours. Abbreviations:i. p. – intraperitoneal; p. o. – peroral; s. c. – subcutaneous; Arg – arginine

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