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Table 1 Effect of D-Arg, L-Arg and DL-Arg on the growth of transplantable animal tumours

From: Role of arginine and its methylated derivatives in cancer biology and treatment

Treatment Tumour Number of animals Daily dose (mg/kg) Duration of treatment (days) Inhibition % Remarks
   Treated Control     
D-Arg 1 Yoshida 6 6 500 p.o. 12 50 p < 0.05
D-Arg 1 Ehrlich s.c. 10 10 500 i.p. 10 20 p < 0.1
L-Arg3 Yoshida 10 10 400 i.p. 10 -40 Enhancement p < 0.05
L-Arg3 Yoshida 10 10 400 p.o. 9 -30 Enhancement p < 0.1
L-Arg2 Ehrlich s.c. 10 10 500 i.p. 12 -40 Enhancement p < 0.05
DL-Arg3 Ehrlich s.c. 10 10 500 i.p. 12 - -
  1. 1Serva (USA), 2Ajinomoto (Japan), 3Reanal (Hungary) Animals were sacrificed 24 hours after the last treatment and tumour weight was measured. Inhibition or enhancement is given as per cent of the control tumours. Abbreviations:i. p. – intraperitoneal; p. o. – peroral; s. c. – subcutaneous; Arg – arginine