Figure 1
From: Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases
CFSE staining of MoCR cells after 24 (A) and 120 (C) hours of treatment. The percent of cells at each cell division was assessed by measuring the level of CFSE fluorescence by FACs. Only divisions with sufficient numbers of cells were assessed. At 24 hours almost all cells were either undivided or had divided twice, while by 120 hours all cells had divided at least 8 times. Proliferation was, in general, inhibited by CGP42112A treatment as indicated by the lower percentage of cells with more divisions. Reduced divisions were also seen at divisions 5 to 7 at time points 48 and 72 hours (P values between 0.058 and 0.088). Significant P values are shown with an * and solid line, while those of interest with P values between 0.1 and 0.05 are indicated with a dotted line and no *. Data are presented as mean ± S.E.M.