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Table 1 Selection of candidate genes by DNA microarray

From: Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR

Gene Cell lines by histopathological subtype
  AD SQ LC SC
  A549 ABC-1 EBC-1 LK-2 LU65 LU99 STC 1 RERF-LC-MA
AMY2A -1.22 0.87 3.68 ** 0.68 2.50 * 1.90 2.91 * 1.36
BEX1 3.25 5.69 7.36 ** 3.08 -0.17 2.86 4.72 * 5.72
CDH1 1.85 3.70 ** 1.87 3.85 ** -0.41 5.20 0.48 -0.70
CSTA 2.54 ** 4.79 ** -1.06 0.80 0.09 -1.93 2.18 ** 0.33
DUSP4 4.24 ** 2.34 ** 4.91 ** 1.26 4.12 ** 0.96 -3.21 2.16 *
FOSL1 -1.26 -1.73 3.27 ** -2.62 2.10 ** 2.44 ** -4.13 2.17 **
FOXG1 -0.19 3.78 -0.20 0.65 -0.16 1.14 5.63 ** 0.17
HMGA1 -0.59 0.24 2.82 ** 0.82 1.68 ** 3.24 ** 0.49 2.81 **
IGSF3 5.61 ** 4.86 -0.12 6.35 * 0.19 1.28 4.71 4.62
INADL 2.44 3.70 2.50 7.65 ** 0.48 1.48 0.80 2.30
ISL1 0.31 -0.45 0.08 2.21 4.61 0.10 -0.74 3.96
MALL 2.20 ** 2.39 ** 2.44 ** -0.07 3.86 ** 1.54 * N.D. 2.36 **
PLAU -3.61 ** -7.21 ** -0.02 -6.75 ** -1.82 ** -1.17 ** -6.95 ** -1.62 **
RAB25 -0.39 6.39 ** 3.37 5.33 ** 0.65 0.44 -2.87 -1.18
S100A2 -0.70 -0.02 4.73 ** 0.08 2.95 ** 1.66 -1.01 4.76 **
S100P 6.28 ** 8.57 ** -0.47 5.00 6.80 ** 0.38 0.39 0.13
SLCO4A1 0.13 2.92 2.81 1.52 4.74 * 6.67 ** 2.83 1.78
STMN1 -1.44 1.41 ** 1.49 ** 1.41 ** 0.44 0.68 2.07 ** 2.21 **
TGM2 -0.56 -2.93 ** 0.46 -5.61 ** -0.39 -1.99 -7.62 ** -5.52 **
  1. Total RNA was extracted from each cultured cell line and reverse-transcribed to produce cDNA. cDNA samples from cancer cells (labeled with Alexa 555) and from normal cells (labeled with Alexa 647) were mixed and hybridized to a DNA microarray that was then scanned with a DNA microarray scanner (n = 6). The ratio of cancer cells to control cells, based on the relative intensities of the two fluorescence signals, was calculated using ArrayGauge. *p < 0.05, **p < 0.01 with Dunnett's test.