Table 1 Chromosomal distribution of the Bcl-2 family members in the human genome.
From: Wnt signal transduction pathway and apoptosis: a review
Survival factors | Bax-like death factors | BH3 domain only death factors | |||||
|---|---|---|---|---|---|---|---|
GENE | LOCUS | GENE | LOCUS | GENE | LOCUS | GENE | LOCUS |
Bcl-2 | 18q21.33 | Bak | 6p21.31 | Bad | 11q13.1 | Hrk | 12q24.22 |
Bcl2A1 (Bfl-1) | 15q25.1 | Bax | 19q13.33 | Bcl2L11(BimL/Bod) | 2q13 | PMAIP1 (Noxa) | 18q21.32 |
Bcl2-L-10(Boo/DIVA) | 15q21.2 | Bcl-xs | 20q11.21 | Bid | 22q11.21 | PUMA | 19q13.32 |
Bcl2L2 (Bcl-w) | 14q11.2 | Bok | 2q37.3 | Bik | 22q13.2 | BNIP3 | 10q26.3 |
Bcl-xL | 20q11.21 | Blk | 8p23.1 | ||||
Mcl-1 | 1q21.2 | Bmf | 15q15.1 | ||||