Figure 6

The Microtopography of the ECM significantly impacts G/F actin ratios in less and more tumorigenic colon cancer cell-lines. The G/F actin ratios in Caco-2 E cells plated on either a pit or a post microtopography was significantly lower as compared to cells plated on a planar surface (p < 0.05). In contrast, the G/F actin ratio in SW620 cells plated on a post microtopography was significantly higher than as compared to cells plated on either a planar surface or a pit microtopography (p < 0.01). When plated on a planar surface, the G/F actin ratio of SW620 cells is significantly lower than the G/F actin ratio of Caco-2 E cells. Where as, the G/F actin ratio in Caco-2 E cells is significantly lower than SW620 cells when plated on a post microtopography. (* = p < 0.01; ** = p < 0.05).