TY - JOUR AU - Sagar, Jayesh AU - Sales, Kevin AU - Taanman, Jan-Willem AU - Dijk, Sas AU - Winslet, Marc PY - 2010 DA - 2010/09/06 TI - Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria JO - Cancer Cell International SP - 31 VL - 10 IS - 1 AB - Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance and cancer metastasis are yet to be eliminated. Recently, doxycycline has been reported to have cytotoxic and anti-proliferating properties in various cancer cells. In this study, whether doxycycline was apoptosis threshold lowering agent in colorectal cancer cells by targeting mitochondria was answered. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-10-31 DO - 10.1186/1475-2867-10-31 ID - Sagar2010 ER -