M344 enhances the cytotoxicity of cisplatin. A, MCF-7 and SK-OV3 cell lines treated with cisplatin (0-10 μg/ml) in the presence (grey) or absence (black) of M344 (1 μM) for 48 hrs was assessed for cell viability employing the MTT assay. Data is represented as a percentage of MTT activity where untreated cells were taken to be 100%. Error bars are representative of six replicates of two independent experiments. B, Phase contrast images of MCF-7 cells treated with no treatment (control), cisplatin (2 μg/ml), M344 (1 μM) and cisplatin and M344 in combination for 48 hrs.