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Figure 5 | Cancer Cell International

Figure 5

From: Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination

Figure 5

ATF3 mediates, in part, the enhanced cytotoxicity between M344 and cisplatin. A, A549 cells treated with cisplatin alone (0-10 μg/ml), or with M344 (1 μM) for 48 hrs were assessed for cell viability as measured by MTT activity. Data is represented as a percentage of MTT activity where untreated cells were taken to be 100%. Error bars are representative of six replicates of two independent experiments. B, A549 cells treated with solvent control, M344 alone (1 and 5 μM), cisplatin (2 μg/ml) alone or in combination with M344 (1 and 5 μM) were analyzed by Western blotting for ATF3, PARP and actin.

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