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Table 1 Ngb, Cygb and CA IX expression in tissue microarrays of human solid tumors and adjacent normal tissues

From: Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues

Organ

NGB

CGB

CAIX

Comments

Normal

    

Skin

1

1

0

Cygb: + desquamating cells

Breast

1

1

0

Ngb & Cygb: + ductal cells

Spleen

2

1

0

 

Lymph node

3

1

1

Ngb & Cygb: + white pulp, lymph

Skeletal muscle

0

0

0

 

Lung

0

0

0

 

Salivary gland

2

2

1

Ngb & Cygb: + ductal cells

Liver

3

2

1

 

Gallbladder

2

1

1

 

Pancreas

3

0

0

 

Tonsil

2

1

1

 

Esophagus

2

0

1

 

Stomach, antrum

2

0

1

Ngb & Cygb: + ductal cells

Stomach, fundus

3

2

2

Ngb & Cygb: + ductal cells

Small bowel

3

1

2

Ngb & Cygb: + ductal cells

Kidney, cortex

3

2

1

Ngb & Cygb: + collecting ducts & tubules; - glomeruli

Kidney, medulla

3

2

1

Ngb & Cygb: + collecting ducts & tubules; - glomeruli

Urinary bladder

3

1

1

 

Prostate

4

1

1

 

Testis

1

0

0

Ngb & Cygb: + ductal cells

Uterine cervix

1

1

0

Ngb & Cygb: + desquamating cells, - basal layer

Endometrium

2

0

0

Ngb & Cygb: + ductal cells

Myometrium

2

1

1

 

Placenta

1

0

0

Ngb & Cygb: + ductal cells

Adrenal gland

NE

2

0

Cygb: + ductal cells

Thyroid

NE

NE

NE

 

Cerebrum

3

3

1

 

Cerebellum

2

2

1

 

Tumor

    

Skin

1

1

1

 

Skin

NE

NE

NE

Ngb & Cygb: indistinguishable from melanin

Subcutis

1

0

0

 

Breast

4

1

0

Ngb & Cygb: + ductal cells

Breast

3

1

2

Ngb & Cygb: + ductal cells

Hodgkins

    

lymphoma

3

2

0

 

Bone

5

0

0

 

Lung

3

0

0

 

Lung

2

1

1

 

Liver

4

2

0

 

Liver

4

3

2

 

Liver

5

2

2

 

Esophagus

2

0

1

 

Stomach

1

 

0

 

Stomach

3

 

1

 

Stomach

3

 

0

 

Duodenum

1

??

0

 

Sigmoid colon

4

 

0

 

Rectum

4

 

1

Ngb: + ductal cells

Kidney

4

 

0

Ngb: + villi, - stroma; Cygb:+ normal & tumor cells

Urinary bladder

1

 

3

Ngb: + infiltrating cells

Prostate

3

 

1

Ngb: + ductal cells

Testis

2

 

0

Ngb: + ductal cells

Uterine cervix

2

 

1

 

Endometrium

1

 

1

Ngb: some + ductal cells

Ovary

2

 

0

 

Ovary

3

 

0

 

Ovary

1

 

1

 

Thyroid

2

 

3

 
  1. Tissue microarrays constructed from cores obtained from various human solid tumors and normal adjacent tissues were purchased from IMGENEX Corporation (San Diego, CA). Immunopositive staining for Ngb, Cygb and CA IX was assessed by two observers who noted the overall tissue staining and the presence of positively stained focal regions. Each section was assigned an overall score, where 0 = absence of positively stained cells; 1 = a few positive cells/regions ( < 10%); 2 = weak positive staining, occasional positive foci; 3 = intermediate staining, occasional positive foci ( < 50%); 4 = strongly positive in most of the section, several positive foci; and 5 = strongly positive throughout with many intensely positive foci. Distinct features of the immunostaining patterns in individual tissue cores are noted in the comments column, where "+" = positive staining, "-" = negative staining and NE = not evaluable.
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Cancer Cell International

ISSN: 1475-2867

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