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Figure 7 | Cancer Cell International

Figure 7

From: Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts

Figure 7

3-MC treatment of SV40-immortalized cells induced pro- (mediated by Tag) and anti- (mediated by innate immune system) viral responses, extracellular matrix reorganization, antigen presentation, recruitment of B- and T-cells, activation of MAPK, JAK/STAT, ras, etc. signal pathways, blockage of apoptotic response, and stimulation of proliferation (through blockage of cell cycle arrest), together with activation of oncogenes and inactivation of tumor suppressor genes (tsg's), as well as a DNA damage response (with possibly defective repair). This resulted in a shift of the balance of birth and death toward proliferation, development of a tumorigenic/metastatic phenotype, and sometimes, the vacuoles typical of SV40 viral infection.

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