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Figure 9 | Cancer Cell International

Figure 9

From: α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes

Figure 9

Proposed model for α-TEA-induced ASMase/ceramide dependent apoptosis. The model depicts α-TEA induction of ASMase translocation from cytosol (lysosomes) to the cell surface membrane and the generation of ceramide from hydrolysis of sphingomyelin as an early event (4 hrs) and the colocalization of DR5, Fas, and FADD with ceramide and induction of apoptosis as the cell fate (9-15 hrs). ASMase inhibitor desipramine or ASMase siRNA block α-TEA-initiated events.

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