Skip to main content

Table 1 Summary of characteristics of five clinically tested anti-EpCAM monoclonal antibodies analyzed side by side.

From: Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

Antibody

Binding Affinity [nM]

Binding Domain

ADCC

CDC

Inhibition of MCF-7 Breast Cancer Cell Proliferation

Tolerability in Clinical Trials

 

K D

K on [M/s]

K off [1/s]

 

Mean EC 50 in [ng/ml]

Mean at 20 μg/ml [%]

 

Edrecolomab

1530

2.81 × 104

0.043

Exon 2

264

33

Not Significant

High

Chimeric Edrecolomab

2095

1.67 × 104

0.035

Exon 2

671

60

Not Significant

High

3622W94

0.19

9.49 × 104

1.8 × 10-5

Exon 2

38

70

Not Significant

Low (Pancreatitis)

ING-1

0.16

1.96 × 104

3.2 × 10-5

Exon 2

14

63

Not Significant

Low (Pancreatitis)

Adecatumumab

91

3.46 × 105

0.0316

Exon 5

175

29

Yes

High