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Table 1 Summary of characteristics of five clinically tested anti-EpCAM monoclonal antibodies analyzed side by side.

From: Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

Antibody Binding Affinity [nM] Binding Domain ADCC CDC Inhibition of MCF-7 Breast Cancer Cell Proliferation Tolerability in Clinical Trials
  K D K on [M/s] K off [1/s]   Mean EC 50 in [ng/ml] Mean at 20 μg/ml [%]  
Edrecolomab 1530 2.81 × 104 0.043 Exon 2 264 33 Not Significant High
Chimeric Edrecolomab 2095 1.67 × 104 0.035 Exon 2 671 60 Not Significant High
3622W94 0.19 9.49 × 104 1.8 × 10-5 Exon 2 38 70 Not Significant Low (Pancreatitis)
ING-1 0.16 1.96 × 104 3.2 × 10-5 Exon 2 14 63 Not Significant Low (Pancreatitis)
Adecatumumab 91 3.46 × 105 0.0316 Exon 5 175 29 Yes High