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Table 2 ADCC by five clinically tested anti-EpCAM monoclonal antibodies.

From: Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

Antibody Half-Maximum Lysis [ng/ml]
Maximum Lysis [Percent]
Mean Half-Maximum Lysis [ng/ml] ± S.D.
  Donor  
  1 2 3 4 5  
Edrecolomab 49 n.d. 21 917 68 264 ± 436
  40% n.d. 24% 37% 16%  
Chimeric Edrecolomab 277 1.910 69 515 596 671 ± 721
  84% 43% 19% 94% 44%  
3622W94 4.5 102 2.0 4.9 79 38 ± 48
  77% 42% 43% 82% 46%  
ING-1 2.6 48 0.9 8.2 10 14 ± 19
  90% 47% 23% 78% 54%  
Adecatumumab 50 537 11 100 176 175 ± 211
  86% 39% 27% 76% 53%  
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