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Table 2 ADCC by five clinically tested anti-EpCAM monoclonal antibodies.

From: Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

Antibody

Half-Maximum Lysis [ng/ml]

Maximum Lysis [Percent]

Mean Half-Maximum Lysis [ng/ml] ± S.D.

 

Donor

 
 

1

2

3

4

5

 

Edrecolomab

49

n.d.

21

917

68

264 ± 436

 

40%

n.d.

24%

37%

16%

 

Chimeric Edrecolomab

277

1.910

69

515

596

671 ± 721

 

84%

43%

19%

94%

44%

 

3622W94

4.5

102

2.0

4.9

79

38 ± 48

 

77%

42%

43%

82%

46%

 

ING-1

2.6

48

0.9

8.2

10

14 ± 19

 

90%

47%

23%

78%

54%

 

Adecatumumab

50

537

11

100

176

175 ± 211

 

86%

39%

27%

76%

53%