Table 1 In vitro profile of the NEP/NPs and NFκB/UPS pathways in PC
AD | AI | |
|---|---|---|
LnCaP | PC-3 | |
NEP specific activity (pmoles/μg/min) | 187.25 | 0.375 |
NEP surface expression (%) | 98.89 | 3.81 |
NEP protein | High | None |
ET-1 secretion (pg/ml) | 1.44 | 4.95 |
NFκB subcellular localisation | Cytoplasmic | Mixed |
Nuclear NFκB protein | Low | High |
NFκB-DNA binding signal | Low | Intense |
Total cellular IκBα protein | High | Low |
20S proteasomal activity (RFU/μg) | 45.2 | 208.58 |