Table 3 Major altered pathways

Spliceosome

ACIN1, BCAS2, CRNKL1, EIF4A3, HNRNPA1, HNRNPA3, HNRNPM, HSPA2, LSM3, PRPF8, PUF60, SF3B1, SFRS13A, SFRS3, SFRS6, SFRS9, SNRPB, SNRPD2, SNRPD3, SNRPF, SNRPG, TRA2A, TRA2B

Huntington's disease

ATP5D, ATP5O, CLTA, CLTC, CLTCL1, COX2, COX5B, CYC1, CYCS, DLG4, DNAH2, EP300, NDUFA3, NDUFA5, NDUFS6, PLCB1, POLR2D, RCOR1, SLC25A5, SOD1, SOD2, UQCRB, UQCRC1, UQCRC2, VDAC2

Alzheimer's disease

ADAM10, ATP2A2, ATP2A3, ATP5D, ATP5O, CAPN2, COX2, COX5B, CYC1, CYCS, GRIN2C, HSD17B10, LRP1, NDUFA3, NDUFA5, NDUFS6, PLCB1, PPP3R1, TNF, UQCRB, UQCRC1, UQCRC2

Endocytosis

ARAP3, CLTA, CLTC, CLTCL1, EGFR, EHD1, EPN1, FAM125B, FLT1, HLA-A, HLA-B, HLA-C, HSPA2, MET, PDCD6IP, RAB11B, RAB11FIP3, RAB5C, VTA1

Focal adhesion

CAPN2, CAV1, COL4A2, CRK, DOCK1, EGFR, FLT1, FYN, ILK, ITGA5, ITGB1, MET, PIK3R3, PPP1CC, PPP1R12A, PRKCG, RAC2, THBS1, TLN2, TNXB

Oxidative phosphorylation

ATP5D, ATP5I, ATP5J2, ATP5O, COX2, COX5B, CYC1, NDUFA3, NDUFA5, NDUFS6, PPA2, TCIRG1, UQCRB, UQCRC1, UQCRC2

Parkinson's disease

ATP5D, ATP5O, COX2, COX5B, CYC1, CYCS, NDUFA3, NDUFA5, NDUFS6, SLC25A5, UQCRB, UQCRC1, UQCRC2, VDAC2

Ribosome

RPL10A, RPL21, RPL22, RPL31, RPL3, RPL5, RPL9, RPLP1, RPS12, RPS16, RPS19, RPS20, RPS5, RPS6, RPS7, RPS8

Glycolysis/Gluconeogenesis

ADH1A, ADH1B, AKR1A1, ALDH1B1, ALDH2, ALDOC, DLD, ENO2, GPI, PGAM2, PGM1, PKM2, TPI1

Viral myocarditis

ABL2, CAV1, CYCS, DAG1, FYN, HLA-A, HLA-B, HLA-C, HLA-DRA, HLA-DRB1, MYH15, RAC2

Antigen processing and presentation

CD74, CTSB, CTSS, HLA-A, HLA-B, HLA-C, HLA-DRA, HLA-DRB1, HSPA2, IFI30, PSME2

Cardiac muscle contraction

ATP1B3, ATP2A2, COX2, COX5B, CYC1, TPM2, TPM3, UQCRB, UQCRC1, UQCRC2