Effect of M344 and cisplatin treatments on the levels of BRCA1 protein expression in our panel of cell lines. Western blot analysis of BRCA1 following 24 hrs of treatment with 0.5, 1.0, or 5.0 μM M344 either alone or in combination with 2 μg/ml cisplatin. DMSO is the solvent control for the M344 treatment and 2 μg/ml cisplatin is the control for the combination treatment. The experiment was repeated with similar results. Densitometry readings are normalized to the DMSO solvent control.