Figure 5

Histopathological photomicrographs of the liver of rats of different experimental groups. (a) Liver from control group showing normal hepatic architecture with the central vein (CV) lying at the center of the hepatic lobule surrounded by the hepatocytes (H & E stain-X 400). (b) Liver from NDEA administrated group showing disorganization of hepatic lobular architecture and obvious cellular damage. The hepatocytes lost their normal shape, lost their arrangement and showed megalocytosis (red arrow), hyperchromatic nuclei (blue arrow) as well as nuclear vesiculation and nuclear prominence (black arrow) (H & E stain-X 400). (c) Liver from silymarin pretreated group showing Kupffer cells proliferation (red arrow), minimal nuclear vesiculation and nuclear prominence (blue arrow) (H & E stain-X 400). (d) Liver from EGb pretreated group showing hepatocytes with foamy cytoplasm (red arrow), minimal nuclear vesiculation and nuclear prominence (blue arrow) (H & E stain-X 400). (e) Liver from silymarin posttreated group showing oval cells proliferation (red arrow) (H & E stain-X 400). (f) Liver from EGb posttreated group showing lesser degree of vacuolated hepatocytes (red arrow) (H & E stain-X 400).