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Figure 1 | Cancer Cell International

Figure 1

From: Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro

Figure 1

Chemotherapy induces multidrug resistance in HCC cells. Gemcitabine (11.4 μg/ml or 114 μg/ml) or Doxorubicin (0.15 μg/ml or 1.5 μg/ml) was added to HepG2 cells twice weekly and cultured in RPMI 1640 containing 10% FBS. A: mRNA expression of ATP-binding cassette proteins was assessed by RT-PCR. Columns average of three independent experiments, bars SD. B: protein expression of ATP-binding cassette proteins was assessed by Western blot. C: PGP transport function was assessed by Rhodamine uptake assay and analysed by FACS. *p ≤ 0.05 compared to the untreated control group.

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