Figure 2From: Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitroChemotherapy induces the tyrosine kinase cascade mRNA expression in HCC cells. Gemcitabine (11.4 μg/ml or 114 μg/ml) or Doxorubicin (0.15 μg/ml or 1.5 μg/ml) was added to HepG2 cells twice weekly and cultured in RPMI 1640 containing 10% FBS. A: Tyrosine kinase mRNA expression was assessed by RT-PCR. Columns average of three independent experiments, bars SD. B: protein expression of tyrosine kinases was assessed by Western blot. *p ≤ 0.05; **p ≤ 0.001 compared to the untreated control group.Back to article page