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Figure 4 | Cancer Cell International

Figure 4

From: Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis

Figure 4

Androgen regulation of TRAIL-induced apoptosis in LNCaP cells. After 4 days of culture with ethanol vehicle (Ct: control), or R1881, LNCaP cells were treated with increasing TRAIL concentrations for 24 h. (A): fragmented nuclei were investigated after DAPI staining by fluorescence microscopy. (B): the number of fragmented nuclei was determined in LNCaP treated with increasing TRAIL concentrations for 24 h. The values represent the mean ± SD of fragmented nuclei per 1,000 cells after analysis of 5,000 randomly selected cells per culture and determined from 5 replicate cultures of a representative experiment from 3 independent experiments. *P < 0.005 versus TRAIL treated cells in androgen free and 10 nM R1881 conditions.

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