TY - JOUR AU - Jayanthan, Aarthi AU - Bernoux, Delphine AU - Bose, Pinaki AU - Riabowol, Karl AU - Narendran, Aru PY - 2011 DA - 2011/12/29 TI - Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition JO - Cancer Cell International SP - 44 VL - 11 IS - 1 AB - Currently, Atypical Teratoid Rhabdoid Tumor (AT/RT) constitutes one of the most difficult to treat malignancies in pediatrics. Hence, new knowledge of potential targets for therapeutics and the development of novel treatment approaches are urgently needed. We have evaluated the presence of cytokine pathways and the effects of two clinically available multi-tyrosine kinase inhibitors for cytotoxicity, target modulation and drug combinability against AT/RT cell lines. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-11-44 DO - 10.1186/1475-2867-11-44 ID - Jayanthan2011 ER -