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Table 2 Update on clinical trials for CSC molecular targets

From: Therapeutics formulated to target cancer stem cells: Is it in our future?

Target

Drug

Cancer

Phase

http://clinicaltrials.gov/

Sponsor

    

Identifier

 

Notch

MK0752

Breast

I

NCT00106145

Merck

  

Pancreatic

I, II

NCT01098344

Cancer Research UK

 

RO4929097

Renal cell

II

NCT01141569

University Health Network, Toronto

 

PF-03084014

Leukemia

I

NCT00878189

Pfizer

Hedgehog

GDC-0449

Solid tumors

I

NCT00968981

Genentech

  

Colorectal

II

NCT00636610

Genentech

 

PF04449913

Hematologic

I

NCT00953758

Pfizer

 

BMS833923

Basal cell

I

NCT00670189

Bristol-Myers Squibb

 

LDE225

Medulloblastoma

I

NCT00880308

Novartis

  1. Modified from (Ref. [44])
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