TY - JOUR AU - Kapp, Friedrich G. AU - Sommer, Anette AU - Kiefer, Thomas AU - Dölken, Gottfried AU - Haendler, Bernard PY - 2012 DA - 2012/01/18 TI - 5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis JO - Cancer Cell International SP - 1 VL - 12 IS - 1 AB - Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments. Identifying novel drug targets for this indication may open the way for new treatment strategies. Comparison of gene expression profiles of NSCLC and normal adjacent tissue (NAT) allowed to determine that 5-alpha-reductase type I (SRD5A1) was up-regulated in NSCLC compared to NAT. This raised the question whether SRD5A1 was involved in sustained proliferation and survival of NSCLC. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-12-1 DO - 10.1186/1475-2867-12-1 ID - Kapp2012 ER -