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Figure 2 | Cancer Cell International

Figure 2

From: 5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis

Figure 2

Expression of SRD5A1 in lung tumors, NAT and lung cell lines. (A) Three independent probesets (204675_at, 210959_at, and 211056_at) were used to measure the SRD5A1 mRNA levels using the HGU133Plus2.0 array. The bar chart indicates that SRD5A1 was significantly and consistently up-regulated in the NSCLC samples compared to NAT. Comparison of the signal intensities showed a 3.3- and 6.3-fold stronger signal of SRD5A1 mRNA in adenocarcinoma and SCC of the lung, respectively, when compared to NAT. The mean values with one standard deviation are depicted on the right. (B) For eight cases of adenocarcinoma (AdenoCa) and seven cases of SCC, matching samples from cancer and NAT were available. Here, a pairwise comparison of the samples is displayed. In all paired cases, SRD5A1 is expressed at a higher level in the cancer than in the NAT samples. (C) Four NSCLC cell lines were analyzed using the Array Northern database. The results for the SRD5A1-specific probeset 204675_at are shown. The numbers indicate the number of replicates analyzed. Expression levels in the NSCLC cell lines A549 and NCI-H460 (indicated with an arrowhead), and LXF-289 and NCI-H322 (abbreviated H-322) are shown.

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