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Figure 1 | Cancer Cell International

Figure 1

From: Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation

Figure 1

Measurement of relative-fold increase (RFI): FA modulation of HPV effects. Analysis of RFI in CAL27 cells revealed the growth stimulating effects of HPV16, HPV18, FA [100] and FA [400] are reduced or inhibited when HPV and FA are concomitantly administered. Similarly, SCC15 cell growth stimulated by HPV18, FA [100 μg/mL] and FA [400 μg/mL] is either reduced or inhibited by concomitant HPV and FA administration. SCC25 cell growth, stimulated by HPV16, FA [100 μg/mL] and FA [400 μg/mL] is also significantly reduced, although not completely inhibited by concomitant HPV and FA administration. HGF-1 cell growth, stimulated by HPV16 and HPV18 but not FA administration, was robustly enhanced by concomitant administration of HPV and FA. Both HPV16 and HPV18 enhanced HGF-1 proliferation at either concentration of FA [100 or 400 μg/mL].

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Cancer Cell International

ISSN: 1475-2867

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