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Figure 3 | Cancer Cell International

Figure 3

From: The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase

Figure 3

Crystal structure of bovine ANT and spacing of the matrix facing cysteine thiols. A side view of the structure [15] is shown in part A. The matrix facing cysteine residues are in yellow space-filling representation. The cysteine numbering is for the human protein. The corresponding bovine numbering is Cys56, Cys159 and Cys256. The yellow background represents the approximate position of the inner-mitochondrial membrane. The spacing of the three unpaired cysteine residues is shown in part B. The structures were generated from PDB 1OKC using PyMol [31].

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