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Figure 6 | Cancer Cell International

Figure 6

From: Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids

Figure 6

Molecular network of downregulated genes in U373MG cells following exposure to ET-770, the compound 1a. Entrez Gene IDs of 426 downregulated genes in U373MG cells following a 24 hour-exposure to the compound 1a were imported into the Functional Annotation tool of DAVID. The KEGG pathways closely related to the set of imported genes were identified. The ErbB (EGFR) signaling pathway (hsa04012), identified as the first-rank downregulated pathway (Table 2), is shown, where downregulated genes are colored by blue.

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Cancer Cell International

ISSN: 1475-2867

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