ET-770 (the Compound 1a) | ET-770 Derivative (the Compound 3) | RM (the Compound 2a) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Downregulated Genes (n = 426) | Downregulated Genes (n = 417) | Downregulated Genes (n = 274) | |||||||||
Rank | Gene Symbol | Gene Name | Fold Change | Rank | Gene Symbol | Gene Name | Fold Change | Rank | Gene Symbol | Gene Name | Fold Change |
1 | SSBP2 | single-stranded DNA binding protein 2 | 0.040 | 1 | PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.043 | 1 | PSD3 | pleckstrin and Sec7 domain containing 3 | 0.068 |
2 | ELMO1 | engulfment and cell motility 1 | 0.049 | 2 | SSBP2 | single-stranded DNA binding protein 2 | 0.053 | 2 | MST131 | MSTP131 | 0.099 |
3 | ODZ2 | odz, odd Oz/ten-m homolog 2 (Drosophila) | 0.053 | 3 | NLGN1 | neuroligin 1 | 0.055 | 3 | PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.106 |
4 | PRKD1 | protein kinase D1 | 0.068 | 4 | CD180 | CD180 molecule | 0.068 | 4 | EXOC6B | exocyst complex component 6B | 0.114 |
5 | NLGN1 | neuroligin 1 | 0.072 | 5 | EPHA3 | EPH receptor A3 | 0.073 | 5 | ELMO1 | engulfment and cell motility 1 | 0.125 |
6 | MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.072 | 6 | PRKD1 | protein kinase D1 | 0.075 | 6 | DPYD | dihydropyrimidine dehydrogenase | 0.125 |
7 | SBF2 | SET binding factor 2 | 0.088 | 7 | PSD3 | pleckstrin and Sec7 domain containing 3 | 0.080 | 7 | DIAPH2 | diaphanous homolog 2 (Drosophila) | 0.128 |
8 | EPHA3 | EPH receptor A3 | 0.089 | 8 | ELMO1 | engulfment and cell motility 1 | 0.084 | 8 | PDE1C | phosphodiesterase 1 C, calmodulin-dependent 70 kDa | 0.133 |
9 | PSD3 | pleckstrin and Sec7 domain containing 3 | 0.089 | 9 | ODZ2 | odz, odd Oz/ten-m homolog 2 (Drosophila) | 0.084 | 9 | FAM172A | family with sequence similarity 172, member A | 0.138 |
10 | ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.094 | 10 | CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.094 | 10 | FRMD5 | FERM domain containing 5 | 0.139 |
Upregulated Genes (n = 45) | Upregulated Genes (n = 84) | Upregulated Genes (n = 9) | |||||||||
Rank | Gene Symbol | Gene Name | Fold Change | Rank | Gene Symbol | Gene Name | Fold Change | Rank | Gene Symbol | Gene Name | Fold Change |
1 | OSR2 | odd-skipped related 2 (Drosophila) | 6.10 | 1 | AKAP5 | A kinase (PRKA) anchor protein 5 | 6.42 | 1 | DENND2C | DENN/MADD domain containing 2 C | 4.28 |
2 | HBEGF | heparin-binding EGF-like growth factor | 5.12 | 2 | SLC25A19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 | 4.90 | 2 | ZNF844 | zinc finger protein 844 | 4.07 |
3 | AKAP5 | A kinase (PRKA) anchor protein 5 | 4.89 | 3 | OSR2 | odd-skipped related 2 (Drosophila) | 4.86 | 3 | HBEGF | heparin-binding EGF-like growth factor | 4.02 |
4 | CSNK1G1 | casein kinase 1, gamma 1 | 4.69 | 4 | ZNF844 | zinc finger protein 844 | 4.79 | 4 | OSR2 | odd-skipped related 2 (Drosophila) | 3.52 |
5 | IL1A | interleukin 1, alpha | 4.66 | 5 | HBEGF | heparin-binding EGF-like growth factor | 4.63 | 5 | LRRTM2 | leucine rich repeat transmembrane neuronal 2 | 3.44 |
6 | GABRQ | gamma-aminobutyric acid (GABA) receptor, theta | 4.28 | 6 | CDC25A | cell division cycle 25 homolog A (S. pombe) | 4.38 | 6 | TSPYL2 | TSPY-like 2 | 3.28 |
7 | ZNF844 | zinc finger protein844 | 4.03 | 7 | ZNF684 | zinc finger protein 684 | 4.24 | 7 | TLCD1 | TLC domain containing 1 | 3.10 |
8 | E2F2 | E2F transcription factor 2 | 3.82 | 8 | TLCD1 | TLC domain containing 1 | 4.10 | 8 | RHEBL1 | Ras homolog enriched in brain like 1 | 3.08 |
9 | IL17RB | interleukin 17 receptor B | 3.79 | 9 | GPATCH4 | G patch domain containing 4 | 4.06 | 9 | GABRQ | gamma-aminobutyric acid (GABA) receptor, theta | 3.00 |
10 | B7H6 | B7 homolog 6 | 3.75 | 10 | CHAC2 | ChaC, cation transport regulator homolog 2 (E. coli) | 4.01 |