Table 2 Analgesic effect of the subcutaneous administration of crude extract and its semi-purified fractions (F1-F3) of the defensive secretion of Spongia officinalis in the acetic acid 1% writhing test in mice
Treatment | Dose (mg/kg) | Number of writhes ± s.e.m. | inhibition of writhing (%) |
|---|---|---|---|
Control (saline 10 ml/kg) | - | 82.33 ± 12.45 | - |
Crude extract | 100 | 41.83 ± 12.52** | 49.19 |
200 | 39 ± 5.76** | 52.63 | |
400 | 31 ± 3.46** | 62.34 | |
F1 | 200 | 34 ± 3.79** | 58.7 |
F2 | 50 | 24 ± 2.09** | 70.85 |
100 | 18.5 ± 5.43** | 77.53 | |
200 | 12 ± 4** | 85.42 | |
F3 | 200 | 37 ± 3.88** | 54.65 |
Lysine Acetylsalicylate (reference drug) | 200 | 26.16 ± 8.37** | 68.21 |