Table 3 Analgesic effect of the subcutaneous administration of crude extract and its semi-purified fractions (F1-F3) of the defensive secretion of Spongia officinalis in the PBQ writhing test in mice
Treatment | Dose (mg/kg) | Number of writhes ± s.e.m. | inhibition of writhing (%) |
|---|---|---|---|
Control (saline 10 ml/kg) | - | 39 ± 2.6 | - |
Crude extract | 100 | 14.33 ± 5.16** | 63.24 |
200 | 12.33 ± 4.8** | 68.37 | |
400 | 9.66 ± 5.08** | 75.21 | |
F1 | 200 | 12 ± 3.74** | 69.23 |
F2 | 50 | 11 ± 4.19** | 71.79 |
100 | 8 ± 3.4** | 79.48 | |
200 | 7 ± 2.36** | 82.05 | |
F3 | 200 | 11.33 ± 4.32** | 70.94 |
Acetylsalicylate of lysine (reference drug) | 200 | 10 ± 2.6** | 74.35 |