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Table 1 Anti-inflammatory effect of the intraperitoneal administration of methanol extract and its semi-purified fractions (F2-F3) of Spongia officinalis in Carrageenan-induced rat paw edema test

From: Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge

Treatment Dose (mg/kg) Edema (10-2ml) Edema inhibition (%)
  1h 3h 5h 1h 3h 5h
  1h 3h 5h 1h 3h 5h
Control - 20.08±6.5 60.49±1.3 59.99±0.8 - - -
Methanol extract 25 17.46±5.1ns 34.78±5.3** 40.49±6.17** 13.04 42.5 32.5
  50 16.02±0.78* 28.61±1.29** 32.99±1.26** 20.17 52.7 45
  100 16.33±5.2* 23.16±1,14** 26.87±1.16** 18.67 61.71 55.20
Fraction F2 50 17.12±1.37ns 25.37±0.6** 29.12±4.17** 14.74 58.05 51.45
Fraction F3 50 13.5±2.9** 16.42±2.5** 21.7±3.55** 32.76 72.85 63.82
ASL (Reference drug) 300 13.71±3.27** 22.80±0.8** 22.83±4.12** 31.72 62.3 61.94
  1. Values are expressed as mean±s.e.m. *P<0.01, **P<0.001, ns: not significant. n=6 animals.