Table 1 Anti-inflammatory effect of the intraperitoneal administration of methanol extract and its semi-purified fractions (F2-F3) of Spongia officinalis in Carrageenan-induced rat paw edema test

3h

5h

Control

-

20.08±6.5

60.49±1.3

59.99±0.8

-

-

-

Methanol extract

25

17.46±5.1^ns

34.78±5.3^**

40.49±6.17^**

13.04

42.5

32.5

50

16.02±0.78^*

28.61±1.29^**

32.99±1.26^**

20.17

52.7

45

100

16.33±5.2^*

23.16±1,14^**

26.87±1.16^**

18.67

61.71

55.20

Fraction F2

50

17.12±1.37^ns

25.37±0.6^**

29.12±4.17^**

14.74

58.05

51.45

Fraction F3

50

13.5±2.9^**

16.42±2.5^**

21.7±3.55^**

32.76

72.85

63.82

ASL (Reference drug)

300

13.71±3.27^**

22.80±0.8^**

22.83±4.12^**

31.72

62.3

61.94