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Figure 1 | Cancer Cell International

Figure 1

From: Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy

Figure 1

Panel A. Levels of γ-interferon mRNA following the administration of GM-CSF after chemotherapy. γ-interferon mRNA levels were measured in 16 patients pre-chemotherapy/GM-CSF administration and post-GM-CSF/chemotherapy administration by quantitative real time PCR of peripheral blood mononuclear cells. γ-interferon mRNA levels were normalized against the housekeeping gene β-actin mRNA. There was no statistically significant change between the two groups. Panel B. Levels of T-bet transcription factor mRNA following the administration of GM-CSF after chemotherapy. T-bet transcription factor mRNA levels were measured in 16 patients pre-chemotherapy/GM-CSF administration and post-GM-CSF/chemotherapy administration by quantitative real time PCR of peripheral blood mononuclear cells. T-bet transcription factor mRNA levels were normalized against the housekeeping gene β-actin mRNA. There was an approximate 1.7 fold decrease in T-bet transcription factor mRNA levels following the administration of GM-CSF after chemotherapy (p = 0.043). The statistical significance was determined by a Wilcoxin matched pairs test.

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Cancer Cell International

ISSN: 1475-2867

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