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Table 1 Effect of DFMO or DENSPM on intracellular accumulation of cisplatin and BBR 3464 in LU-HNSCC-4 cells. a

From: Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion

Pre-treatment

Platinum accumulation (μg Pt/106 cells)

 

Cisplatin

BBR 3464

Control medium

0.8 ± 0.1

1.0 ± 0.1

5 μM DENSPM

0.8 ± 0.1

1.2 ± 0.1

10 μM DENSPM

0.9 ± 0.1

0.7 ± 0.2

25 μM DFMO

0.9 ± 0.1

2.2 ± 0.3*

75 μM DFMO

0.8 ± 0.1

2.4 ± 0.4*

  1. aCells were grown in the absence of DENSPM or DFMO 48 h and then the medium was changed and fresh medium added before a 1 h exposure to cisplatin (7.5 μM) or BBR 3464 (0.5 μM). Values are mean from three independent experiments in each of which there were at least two independent samples  ±  SEM. * p   0.002.