From: Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion
Pre-treatment
Platinum accumulation (μg Pt/106 cells)
Cisplatin
BBR 3464
Control medium
0.8 ± 0.1
1.0 ± 0.1
5 μM DENSPM
1.2 ± 0.1
10 μM DENSPM
0.9 ± 0.1
0.7 ± 0.2
25 μM DFMO
2.2 ± 0.3*
75 μM DFMO
2.4 ± 0.4*