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Table 1 Effect of DFMO or DENSPM on intracellular accumulation of cisplatin and BBR 3464 in LU-HNSCC-4 cells. a

From: Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion

Pre-treatment Platinum accumulation (μg Pt/106 cells)
  Cisplatin BBR 3464
Control medium 0.8 ± 0.1 1.0 ± 0.1
5 μM DENSPM 0.8 ± 0.1 1.2 ± 0.1
10 μM DENSPM 0.9 ± 0.1 0.7 ± 0.2
25 μM DFMO 0.9 ± 0.1 2.2 ± 0.3*
75 μM DFMO 0.8 ± 0.1 2.4 ± 0.4*
  1. aCells were grown in the absence of DENSPM or DFMO 48 h and then the medium was changed and fresh medium added before a 1 h exposure to cisplatin (7.5 μM) or BBR 3464 (0.5 μM). Values are mean from three independent experiments in each of which there were at least two independent samples  ±  SEM. * p   0.002.