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Table 1 Major altered pathways that include at least 10 differentially expressed proteins, underline indicates the protein specific expressed in cancer stroma

From: Stromal proteome expression profile and muscle-invasive bladder cancer research

Pathway

Gene name

Metabolic pathways

ACAA1, ACADSB, ACO2, ACOX1, ACSL5, ACSM1, ACSM3, ADH1B, ADSS, AK2, AKR1B10, ALDH1B1, ALDH4A1, APIP, APRT, ASAH1, ATIC, ATP5I, ATP6V1E1, BCKDHA, BCKDHB, CAT, CBS, CHPF, COMT, COX17, COX5B, CS, CYC1, CYP19A1, DAD1, DBT, DDOST, DGKI, DLAT, DLD, DLST, DUT, FASN, FH, G6PD, GANAB, GNPDA1, GOT2, GRHPR, HADH, HADHB, HIBADH, HK1, HMGCL, HMGCS2, HSD17B4, IDH1, IMPDH2, ITPA, ITPKA, LAP3, MAT2A, NANS, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, NFKB1, NME2, NOS3, OGDH, Cav-1, PAICS, PCK2, PDXK, PFKP, PGD, PGM2, PHPT1, PNPO, POLR2D, PRDX6, SDHB, SPTLC1, SUCLG2, TYMP, UGDH, UQCRB, UQCRC1

Spliceosome

ACIN1, BCAS2, CRNKL1, HNRNPA1, HSPA2, HSPA6, NHP2L1, PUF60, RBM8A, RBMX, SF3A3, SF3B1, SF3B2, SFRS13A, SFRS2, SFRS3, SFRS4, SFRS5, SFRS9, SNRNP200, SNRPB, SNRPC, SNRPD3, SNRPF, SNRPG, TRA2B, U2AF2

Regulation of actin cytoskeleton

ARPC1B, ARPC2, ARPC3, ARPC5, CDC42, CFL2, CRK, ENAH, IQGAP3, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, MYH14, MYLK, PIK3CB, ROCK2, RRAS2, SSH1, SSH3, WASF2

Ribosome

RPL18, RPL19, RPL22, RPL23, RPL23A, RPL31, RPL38, RPL5, RPL7A, RPL9, RPLP0, RPLP1, RPS10, RPS17, RPS20, RPS25, RPS4X, RPS7

Focal adhesion

CDC42, COL3A1, COL4A2, CRK, CTNNB1, FLNC, FLT1, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, MYLK, PIK3CB, RAP1B, ROCK2, TNC, TNXB, VTN, VWF

Proteasome

PSMA3, PSMA4, PSMA5, PSMA7, PSMB2, PSMB7, PSMC1, PSMC2, PSMC4, PSMC6, PSMD2, PSMD7, PSME2

Endocytosis

ACAP2, ARFGAP2, CDC42, CHMP5, CLTA, CLTB, DNM2, EEA1, EHD1, EHD2, EHD4, EPN1, FLT1, HLA-C, HSPA2, HSPA6, PDCD6IP, RAB11B, RAB11FIP1, VTA1

Huntington's disease

CASP8, CLTA, CLTB, COX5B, COX7A2, CYC1, CYCS, DCTN1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, POLR2D, SDHB, SOD1, TAF4, UQCRB, UQCRC1

Alzheimer's disease

ADAM10, APOE, ATP2A3, CAPN1, CASP8, COX5B, COX7A2, CYC1, CYCS, LRP1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, PPP3R1, SDHB, UQCRB, UQCRC1

Oxidative phosphorylation

ATP5I, ATP6V1E1, COX17, COX5B, COX7A2, CYC1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, PPA1, SDHB, UQCRB, UQCRC1

Systemic lupus erythematosus

C8G, C9, CTSG, ELANE, H2AFV, H2AFY, HIST1H2AA, HIST1H2BA, HIST2H3A, HIST2H3C, HIST2H3D, HLA-DRB1, SNRPB, SNRPD3, SSB

Valine, leucine and isoleucine degradation

ACAA1, ACADSB, ALDH1B1, BCKDHA, BCKDHB, DBT, DLD, HADH, HADHB, HIBADH, HMGCL, HMGCS2

Pathogenic Escherichia coli infection

ARPC1B, ARPC2, ARPC3, ARPC5, CDC42, CDH1, CTNNB1, CTTN, HCLS1, ITGB1, ROCK2, TUBB3

ECM-receptor interaction

AGRN, COL3A1, COL4A2, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, TNC, TNXB, VTN, VWF

Complement and coagulation cascades

C4BPA, C8G, C9, CFH, CFI, KNG1, PLG, SERPINC1, SERPING1, VWF

Citrate cycle

ACO2, CS, DLAT, DLD, DLST, FH, IDH1, OGDH, PCK2, SDHB, SUCLG2