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Table 1 Major altered pathways that include at least 10 differentially expressed proteins, underline indicates the protein specific expressed in cancer stroma

From: Stromal proteome expression profile and muscle-invasive bladder cancer research

Pathway Gene name
Metabolic pathways ACAA1, ACADSB, ACO2, ACOX1, ACSL5, ACSM1, ACSM3, ADH1B, ADSS, AK2, AKR1B10, ALDH1B1, ALDH4A1, APIP, APRT, ASAH1, ATIC, ATP5I, ATP6V1E1, BCKDHA, BCKDHB, CAT, CBS, CHPF, COMT, COX17, COX5B, CS, CYC1, CYP19A1, DAD1, DBT, DDOST, DGKI, DLAT, DLD, DLST, DUT, FASN, FH, G6PD, GANAB, GNPDA1, GOT2, GRHPR, HADH, HADHB, HIBADH, HK1, HMGCL, HMGCS2, HSD17B4, IDH1, IMPDH2, ITPA, ITPKA, LAP3, MAT2A, NANS, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, NFKB1, NME2, NOS3, OGDH, Cav-1, PAICS, PCK2, PDXK, PFKP, PGD, PGM2, PHPT1, PNPO, POLR2D, PRDX6, SDHB, SPTLC1, SUCLG2, TYMP, UGDH, UQCRB, UQCRC1
Spliceosome ACIN1, BCAS2, CRNKL1, HNRNPA1, HSPA2, HSPA6, NHP2L1, PUF60, RBM8A, RBMX, SF3A3, SF3B1, SF3B2, SFRS13A, SFRS2, SFRS3, SFRS4, SFRS5, SFRS9, SNRNP200, SNRPB, SNRPC, SNRPD3, SNRPF, SNRPG, TRA2B, U2AF2
Regulation of actin cytoskeleton ARPC1B, ARPC2, ARPC3, ARPC5, CDC42, CFL2, CRK, ENAH, IQGAP3, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, MYH14, MYLK, PIK3CB, ROCK2, RRAS2, SSH1, SSH3, WASF2
Ribosome RPL18, RPL19, RPL22, RPL23, RPL23A, RPL31, RPL38, RPL5, RPL7A, RPL9, RPLP0, RPLP1, RPS10, RPS17, RPS20, RPS25, RPS4X, RPS7
Focal adhesion CDC42, COL3A1, COL4A2, CRK, CTNNB1, FLNC, FLT1, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, MYLK, PIK3CB, RAP1B, ROCK2, TNC, TNXB, VTN, VWF
Proteasome PSMA3, PSMA4, PSMA5, PSMA7, PSMB2, PSMB7, PSMC1, PSMC2, PSMC4, PSMC6, PSMD2, PSMD7, PSME2
Endocytosis ACAP2, ARFGAP2, CDC42, CHMP5, CLTA, CLTB, DNM2, EEA1, EHD1, EHD2, EHD4, EPN1, FLT1, HLA-C, HSPA2, HSPA6, PDCD6IP, RAB11B, RAB11FIP1, VTA1
Huntington's disease CASP8, CLTA, CLTB, COX5B, COX7A2, CYC1, CYCS, DCTN1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, POLR2D, SDHB, SOD1, TAF4, UQCRB, UQCRC1
Alzheimer's disease ADAM10, APOE, ATP2A3, CAPN1, CASP8, COX5B, COX7A2, CYC1, CYCS, LRP1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, PPP3R1, SDHB, UQCRB, UQCRC1
Oxidative phosphorylation ATP5I, ATP6V1E1, COX17, COX5B, COX7A2, CYC1, NDUFA10, NDUFA4, NDUFA8, NDUFS4, NDUFS6, PPA1, SDHB, UQCRB, UQCRC1
Systemic lupus erythematosus C8G, C9, CTSG, ELANE, H2AFV, H2AFY, HIST1H2AA, HIST1H2BA, HIST2H3A, HIST2H3C, HIST2H3D, HLA-DRB1, SNRPB, SNRPD3, SSB
Valine, leucine and isoleucine degradation ACAA1, ACADSB, ALDH1B1, BCKDHA, BCKDHB, DBT, DLD, HADH, HADHB, HIBADH, HMGCL, HMGCS2
Pathogenic Escherichia coli infection ARPC1B, ARPC2, ARPC3, ARPC5, CDC42, CDH1, CTNNB1, CTTN, HCLS1, ITGB1, ROCK2, TUBB3
ECM-receptor interaction AGRN, COL3A1, COL4A2, ITGA5, ITGA6, ITGAV, ITGB1, ITGB4, TNC, TNXB, VTN, VWF
Complement and coagulation cascades C4BPA, C8G, C9, CFH, CFI, KNG1, PLG, SERPINC1, SERPING1, VWF
Citrate cycle ACO2, CS, DLAT, DLD, DLST, FH, IDH1, OGDH, PCK2, SDHB, SUCLG2