Table 3 Genes down regulated in the pediatric AML compared with normal control

1

HOXB9

Homeobox B9

172. 9526

0. 6802

0. 004

<0. 0001

2

HOXA5

Homeobox A5

925. 5920

3. 4967

0. 004

<0. 0001

3

I D3

I nhi bi t or of DNA bi ndi ng 3

531. 6130

3. 0212

0. 006

<0. 0001

4

I GF2

Insulin-like growth factor 2

3. 4683

0. 0056

0. 002

<0. 0001

5

I D4

I nhi bi t or of DNA bi ndi ng 4

1422. 5193

0. 1906

0. 000

<0. 0001

6

FOXC1

Forkhead box C1

3676. 7938

26. 5854

0. 007

<0. 0001

7

HOXA7

Homeobox A7

15. 3933

0. 2396

0. 016

<0. 0001

8

CXCL1

Chemokine (C-X-C motif) ligand 1

0. 1130

0. 0022

0. 020

<0. 0001

9

HOXC9

Homeobox C9

138. 5471

4. 6762

0. 034

<0. 0001

10

HOXA3

Homeobox A3

16. 0470

0. 5843

0. 036

<0. 0001

11

HOXA4

Homeobox A4

263. 9704

7. 3403

0. 028

<0. 0001

12

DKK3

Dickkopf 3 homolog

8. 4810

0. 3344

0. 039

<0. 0001

13

JUN

Jun pr ot o- oncogene

1005. 8731

35. 1804

0. 035

<0. 0001

14

STAT4

Signal transducer and activator of transcription 4

11. 5854

0. 5332

0. 046

<0. 0001

15

HOXB1

Homeobox B1

23. 4942

0. 8037

0. 034

<0. 0001

16

FGFR1

Fibroblast growth factor receptor 1

3. 7172

0. 2184

0. 059

<0. 0001

17

FOXM1

For khead box M1

789. 1920

177. 9791

0. 226

0. 0008

18

HDAC2

Histone deacetylase 2

2925. 0236

618. 9588

0. 212

0. 0008

19

HMBS

Hydr oxymet hyl bi l ane synt hase

233. 0075

46. 3417

0. 199

0. 0008

20

I D1

I nhi bi t or of DNA bi ndi ng 1

140. 4811

14. 8120

0. 105

0. 0008

21

I D2

I nhi bi t or of DNA bi ndi ng 2

1221. 3259

360. 7765

0. 295

0. 001

22

CDKN2B

Cyclin-dependent kinase inhibitor 2B

23. 9879

5. 1419

0. 214

0. 001

23

DDX1

DEAD ( Asp- Gl u- Al a- Asp) box hel i case 1

2039. 8291

681. 2089

0. 334

0. 001

24

HDAC1

Histone deacetylase 1

1196. 1914

449. 9266

0. 376

0. 002

25

BRCA1

Br east cancer 1, ear l y onset

12. 8548

4. 4127

0. 343

0. 004