Table 1 Summary of marker expression determined by RT-PCR
Stem cell markers | Proliferation, angliogenic, migration markers, growth factors, adhesion | ||
|---|---|---|---|
SOX2 | ++++++ | Ki67 | +++++ |
DACH1 | + | VEGF | +++ |
CD133 | ++++ | HIF1 | + |
Nestin | +++ | CXCR4 | ++ |
Nucleostemin | ++++ | SDF1 | + |
IGF1R | ++ | ||
NCAM | +++ | ||
Glial Cells | PAX6 | ++++ | |
GFAP | ++ | ||
Ephrins receptors and ligands (cell repulsion, adhesion, migration) | |||
Neuronal | EphB1 Receptor | n/a | |
DCX | + | EphB2 Receptors | ++++++ |
MSI | + | EphB3 Receptors | +++++ |
MAP2 | + | EFNB1\ | + |
Neural Specific Endolase | ++++ | EFNB2 | ++ |
Beta-3Tubulin III | + | EFNB3 | + |
MMPs, Peptidases | ++ | ||
MMP2 | +++ | ||
Tumor Suppressors/Oncogenes | TIMP1 | ||
p53 | + | MMP9 | +++ |
PTEN | + | MMP13 | ++++ |
Bmi-1 | ++ | MMP14 | + |
CAV-1 | ++ | Cathepsin B | + |
CAV-2 | + | Cathepsin L | +++ |
c-Myc | +++ | ||
Controls | |||
Proteoglycans | GAPDH | +++ | |
Mucin9 | ++ | Beta-Actin | ++ |
Mucin18 | + | H2O | |
Mucin24 | ++++ | ||
Notch-Family | |||
Notch1 | + | ||
Notch2 | +++ | ||
Notch3 | + | ||
Notch4 | ++ | ||