TY - JOUR AU - Carrassa, L. AU - Damia, G. PY - 2011 DA - 2011// TI - Unleashing Chk1 in cancer therapy JO - Cell Cycle VL - 10 UR - https://doi.org/10.4161/cc.10.13.16398 DO - 10.4161/cc.10.13.16398 ID - Carrassa2011 ER - TY - JOUR AU - Ma, C. X. AU - Janetka, J. W. AU - Piwnica-Worms, H. PY - 2011 DA - 2011// TI - Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics JO - Trends Mol Med VL - 17 UR - https://doi.org/10.1016/j.molmed.2010.10.009 DO - 10.1016/j.molmed.2010.10.009 ID - Ma2011 ER - TY - JOUR AU - Daud, A. AU - Pringett, G. M. AU - Mendelson, D. S. AU - Munster, P. N. AU - Goldman, J. W. AU - Strosberg, J. R. PY - 2010 DA - 2010// TI - A phase I dose-escalation study of SCH 900776, a selective inhibitor of checkpoint kinase 1 (CHK1), in combination with gemcitabine (Gem) in subjects with advanced solid tumors (2010 ASCO Annual Meeting) JO - J Clin Oncol VL - 28 ID - Daud2010 ER - TY - CHAP AU - Schellens, J. H. M. AU - Shapiro, G. AU - Pavlick, A. C. AU - Tibes, R. AU - Leijen, S. AU - Tolaney, S. M. PY - 2011 DA - 2011// TI - Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors (2011 ASCO Annual Meeting) BT - J Clin Oncol ID - Schellens2011 ER - TY - JOUR AU - Zhao, H. AU - Watkins, J. L. AU - Piwnica-Worms, H. PY - 2002 DA - 2002// TI - Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G(2) checkpoints JO - Proc Natl Acad Sci USA VL - 99 UR - https://doi.org/10.1073/pnas.182557299 DO - 10.1073/pnas.182557299 ID - Zhao2002 ER - TY - JOUR AU - Sorensen, C. S. AU - Syluasen, R. G. AU - Falck, J. AU - Schroeder, T. AU - Ronnstrand, L. AU - Khanna, K. K. PY - 2003 DA - 2003// TI - Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A JO - Cancer Cell VL - 3 UR - https://doi.org/10.1016/S1535-6108(03)00048-5 DO - 10.1016/S1535-6108(03)00048-5 ID - Sorensen2003 ER - TY - JOUR AU - Sanchez, Y. AU - Wong, C. AU - Thoma, R. S. AU - Richman, R. AU - Wu, R. Q. AU - Piwnicaworms, H. PY - 1997 DA - 1997// TI - Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25 JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5331.1497 DO - 10.1126/science.277.5331.1497 ID - Sanchez1997 ER - TY - JOUR AU - OConnell, M. J. AU - Raleigh, J. M. AU - Verkade, H. M. AU - Nurse, P. PY - 1997 DA - 1997// TI - Chk1 is a wee1 kinase in the G(2) DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.3.545 DO - 10.1093/emboj/16.3.545 ID - OConnell1997 ER - TY - JOUR AU - Liu, Q. H. AU - Guntuku, S. AU - Cui, X. S. AU - Matsuoka, S. AU - Cortez, D. AU - Tamai, K. PY - 2000 DA - 2000// TI - Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint JO - Genes Dev VL - 14 UR - https://doi.org/10.1101/gad.840500 DO - 10.1101/gad.840500 ID - Liu2000 ER - TY - JOUR AU - Petermann, E. AU - Maya-Mendoza, A. AU - Zachos, G. AU - Gillespie, D. A. F. AU - Jackson, D. A. AU - Caldecott, K. W. PY - 2006 DA - 2006// TI - Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.26.8.3319-3326.2006 DO - 10.1128/MCB.26.8.3319-3326.2006 ID - Petermann2006 ER - TY - JOUR AU - Feijoo, C. AU - Hall-Jackson, C. AU - Wu, R. AU - Jenkins, D. AU - Leitch, J. AU - Gilbert, D. M. PY - 2001 DA - 2001// TI - Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing JO - J Cell Biol VL - 154 UR - https://doi.org/10.1083/jcb.200104099 DO - 10.1083/jcb.200104099 ID - Feijoo2001 ER - TY - JOUR AU - Petermann, E. AU - Woodcock, M. AU - Helleday, T. PY - 2010 DA - 2010// TI - Chk1 promotes replication fork progression by controlling replication initiation JO - Proc Natl Acad Sci USA VL - 107 UR - https://doi.org/10.1073/pnas.1005031107 DO - 10.1073/pnas.1005031107 ID - Petermann2010 ER - TY - JOUR AU - Sorensen, C. S. AU - Hansen, L. T. AU - Dziegielewski, J. AU - Syljuasen, R. G. AU - Lundin, C. AU - Bartek, J. PY - 2005 DA - 2005// TI - The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair JO - Nat Cell Biol VL - 7 UR - https://doi.org/10.1038/ncb1212 DO - 10.1038/ncb1212 ID - Sorensen2005 ER - TY - JOUR AU - Hu, B. C. AU - Wang, H. Y. AU - Wang, X. AU - Lu, H. R. AU - Huang, C. F. AU - Powell, S. N. PY - 2005 DA - 2005// TI - Fhit and CHK1 have opposing effects on homologous recombination repair JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-05-1966 DO - 10.1158/0008-5472.CAN-05-1966 ID - Hu2005 ER - TY - JOUR AU - Kramer, A. AU - Mailand, N. AU - Lukas, C. AU - Syljuasen, R. G. AU - Wilkinson, C. J. AU - Nigg, E. A. PY - 2004 DA - 2004// TI - Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase JO - Nat Cell Biol VL - 6 UR - https://doi.org/10.1038/ncb1165 DO - 10.1038/ncb1165 ID - Kramer2004 ER - TY - JOUR AU - Lam, M. H. AU - Liu, Q. H. AU - Elledge, S. J. AU - Rosen, J. M. PY - 2004 DA - 2004// TI - Chk1 is haploinsufficient for multiple functions critical to tumor suppression JO - Canc Cell VL - 6 UR - https://doi.org/10.1016/j.ccr.2004.06.015 DO - 10.1016/j.ccr.2004.06.015 ID - Lam2004 ER - TY - JOUR AU - Tominaga, Y. AU - Li, C. AU - Wang, R. -. H. AU - Deng, C. -. X. PY - 2006 DA - 2006// TI - Murine Wee1 Plays a Critical Role in Cell Cycle Regulation and Pre-Implantation Stages of Embryonic Development JO - Int J Biol Sci VL - 2 UR - https://doi.org/10.7150/ijbs.2.161 DO - 10.7150/ijbs.2.161 ID - Tominaga2006 ER - TY - JOUR AU - Raleigh, J. M. AU - O’Connell, M. J. PY - 2000 DA - 2000// TI - The G(2) DNA damage checkpoint targets both Wee1 and Cdc25 JO - J Cell Sci VL - 113 ID - Raleigh2000 ER - TY - JOUR AU - Beck, H. AU - Nahse, V. AU - Larsen, M. S. Y. AU - Groth, P. AU - Clancy, T. AU - Lees, M. PY - 2010 DA - 2010// TI - Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase JO - J Cell Biol VL - 188 UR - https://doi.org/10.1083/jcb.200905059 DO - 10.1083/jcb.200905059 ID - Beck2010 ER - TY - JOUR AU - Dominguez-Kelly, R. AU - Martin, Y. AU - Koundrioukoff, S. AU - Tanenbaum, M. E. AU - Smits, V. A. J. AU - Medema, R. H. PY - 2011 DA - 2011// TI - Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease JO - J Cell Biol VL - 194 UR - https://doi.org/10.1083/jcb.201101047 DO - 10.1083/jcb.201101047 ID - Dominguez-Kelly2011 ER - TY - JOUR AU - Bridges, K. A. AU - Hirai, H. AU - Buser, C. A. AU - Brooks, C. AU - Liu, H. F. AU - Buchholz, T. A. PY - 2011 DA - 2011// TI - MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-Defective Human Tumor Cells JO - Clin Cancer Res VL - 17 UR - https://doi.org/10.1158/1078-0432.CCR-11-0650 DO - 10.1158/1078-0432.CCR-11-0650 ID - Bridges2011 ER - TY - JOUR AU - PosthumaDeBoer, J. AU - Wurdinger, T. AU - Graat, H. C. A. AU - Van Beusechem, V. W. AU - Helder, M. N. AU - Van Royen, B. J. PY - 2011 DA - 2011// TI - WEE1 inhibition sensitizes osteosarcoma to radiotherapy JO - BMC Cancer VL - 11 UR - https://doi.org/10.1186/1471-2407-11-156 DO - 10.1186/1471-2407-11-156 ID - PosthumaDeBoer2011 ER - TY - JOUR AU - Rajeshkumar, N. V. AU - De Oliveira, E. AU - Ottenhof, N. AU - Watters, J. AU - Brooks, D. AU - Demuth, T. PY - 2011 DA - 2011// TI - MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts JO - Clin Cancer Res VL - 17 UR - https://doi.org/10.1158/1078-0432.CCR-10-2580 DO - 10.1158/1078-0432.CCR-10-2580 ID - Rajeshkumar2011 ER - TY - JOUR AU - Mir, S. E. AU - Hamer, P. C. D. AU - Krawczyk, P. M. AU - Balaj, L. AU - Claes, A. AU - Niers, J. M. PY - 2010 DA - 2010// TI - In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma JO - Canc Cell VL - 18 UR - https://doi.org/10.1016/j.ccr.2010.08.011 DO - 10.1016/j.ccr.2010.08.011 ID - Mir2010 ER - TY - JOUR AU - Hirai, H. AU - Arai, T. AU - Okada, M. AU - Nishibata, T. AU - Kobayashi, M. AU - Sakai, N. PY - 2010 DA - 2010// TI - MK-1775, a small molecule Wee1 inhibitor, enhances antitumor efficacy of various DNA-damaging agents, including 5-fluorouracil JO - Canc Biol Ther VL - 9 UR - https://doi.org/10.4161/cbt.9.7.11115 DO - 10.4161/cbt.9.7.11115 ID - Hirai2010 ER - TY - JOUR AU - Hirai, H. AU - Iwasawa, Y. AU - Okada, M. AU - Arai, T. AU - Nishibata, T. AU - Kobayashi, M. PY - 2009 DA - 2009// TI - Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents JO - Mol Cancer Ther VL - 8 UR - https://doi.org/10.1158/1535-7163.MCT-09-0463 DO - 10.1158/1535-7163.MCT-09-0463 ID - Hirai2009 ER - TY - JOUR AU - Murrow, L. M. AU - Garimella, S. V. AU - Jones, T. L. AU - Caplen, N. J. AU - Lipkowitz, S. PY - 2010 DA - 2010// TI - Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome JO - Breast Canc Res Treat VL - 122 UR - https://doi.org/10.1007/s10549-009-0571-2 DO - 10.1007/s10549-009-0571-2 ID - Murrow2010 ER - TY - JOUR AU - Iorns, E. AU - Lord, C. J. AU - Grigoriadis, A. AU - McDonald, S. AU - Fenwick, K. AU - Mackay, A. PY - 2009 DA - 2009// TI - Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0005120 DO - 10.1371/journal.pone.0005120 ID - Iorns2009 ER - TY - JOUR AU - Parry, D. AU - Guzi, T. AU - Shanahan, F. AU - Davis, N. AU - Prabhavalkar, D. AU - Wiswell, D. PY - 2010 DA - 2010// TI - Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor JO - Mol Cancer Ther VL - 9 UR - https://doi.org/10.1158/1535-7163.MCT-10-0324 DO - 10.1158/1535-7163.MCT-10-0324 ID - Parry2010 ER - TY - JOUR AU - Davies, K. D. AU - Humphries, M. J. AU - Sullivan, F. X. AU - von Carlowitz, I. AU - Le Huerou, Y. AU - Mohr, P. J. PY - 2011 DA - 2011// TI - Single-Agent Inhibition of Chk1 Is Antiproliferative in Human Cancer Cell Lines In Vitro and Inhibits Tumor Xenograft Growth In Vivo JO - Oncol Res VL - 19 UR - https://doi.org/10.3727/096504011X13079697132961 DO - 10.3727/096504011X13079697132961 ID - Davies2011 ER - TY - JOUR AU - Hamer, P. C. D. AU - Mir, S. E. AU - Noske, D. AU - Van Noorden, C. J. F. AU - Wurdinger, T. PY - 2011 DA - 2011// TI - WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe JO - Clin Cancer Res VL - 17 UR - https://doi.org/10.1158/1078-0432.CCR-10-2537 DO - 10.1158/1078-0432.CCR-10-2537 ID - Hamer2011 ER - TY - JOUR AU - Xiao, Z. AU - Xue, J. AU - Gu, W. Z. AU - Bui, M. AU - Li, G. Q. AU - Tao, Z. F. PY - 2008 DA - 2008// TI - Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors JO - Biomarkers VL - 13 UR - https://doi.org/10.1080/13547500802063240 DO - 10.1080/13547500802063240 ID - Xiao2008 ER - TY - JOUR AU - Davies, K. D. AU - Cable, P. L. AU - Garrus, J. E. AU - Sullivan, F. X. AU - von Carlowitz, I. AU - Huerou, Y. L. PY - 2011 DA - 2011// TI - Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation JO - Canc Biol Ther VL - 12 UR - https://doi.org/10.4161/cbt.12.9.17673 DO - 10.4161/cbt.12.9.17673 ID - Davies2011 ER - TY - JOUR AU - Carrassa, L. AU - Chila, R. AU - Lupi, M. AU - Ricci, F. AU - Celenza, C. AU - Mazzoletti, M. PY - 2012 DA - 2012// TI - Combined inhibition of Chk1 and Wee1 In vitro synergistic effect translates to tumor growth inhibition in vivo JO - Cell Cycle VL - 11 UR - https://doi.org/10.4161/cc.20899 DO - 10.4161/cc.20899 ID - Carrassa2012 ER - TY - JOUR AU - Guzi, T. J. AU - Paruch, K. AU - Dwyer, M. P. AU - Labroli, M. AU - Shanahan, F. AU - Davis, N. PY - 2011 DA - 2011// TI - Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening JO - Mol Cancer Ther VL - 10 UR - https://doi.org/10.1158/1535-7163.MCT-10-0928 DO - 10.1158/1535-7163.MCT-10-0928 ID - Guzi2011 ER - TY - JOUR AU - Bliss, C. I. PY - 1939 DA - 1939// TI - The toxicity of poisons applied jointly JO - Ann Appl Biol VL - 26 UR - https://doi.org/10.1111/j.1744-7348.1939.tb06990.x DO - 10.1111/j.1744-7348.1939.tb06990.x ID - Bliss1939 ER -