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Table 2 List of the VOCs obtained from the tumor-bearing mice that were increased or decreased relative to the control group.

From: Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice

Increased compound

CAS No.

Classification

fold

p-value

1,3-Di-tert-butylbenzene

1014-60-4

ethers

+

0.08

2-(sec-butyl)-4,5-dihydrothiazole

56367-27-2

sulfurs

++

0.01

2,4-Dimethylheptane

2213-23-2

hydrocarbons

+

< 0.01

2,5-Dimethylpyrazine

123-32-0

pyrazines

+

0.07

2,5-Heptanedione

1703-51-1

ketones

+

0.03

2-Acetyl-5-methylfuran

1193-79-9

furans

+

0.02

2-Aminobenzamide

88-68-6

aldehydes

+

0.05

2-Butanone

78-93-3

ketones

+

0.02

2-Ethyl-5-methylfuran

1703-52-2

furans

+

0.06

2-Heptanone

110-43-0

ketones

+

0.04

2-Hexanone

591-78-6

ketones

+

0.03

2-Methoxy-5-methylthiophene

31053-55-1

sulfurs

+

0.02

2-Methylfuran

534-22-5

furans

++

0.01

2-Methylpyrazine

109-08-0

pyrazines

++

0.07

2-Pentanone

107-87-9

ketones

+

0.09

2-Methyl-6-vinylpyrazine

13925-09-2

pyrazines

++

0.02

3-Hexanone

589-38-8

ketones

+

0.1

3-Methyl-1-hexen-3-ol

55145-28-3

alcohols

++

0.01

4-Heptanone

123-19-3

ketones

+

0.03

4-Ketoisophorone

1125-21-9

ketones

+

0.05

4-Methoxyphenol

150-76-5

phenols

+

0.02

4-Methyloctane

2216-34-4

hydrocarbons

+

0.02

5-Hepten-2-one

6714-00-7

ketones

+

0.04

6-methyl-3-heptanone

624-42-0

ketones

+

0.03

Acetone

67-64-1

ketones

+

0.03

Acetophenone

98-86-2

ketones

+

0.03

Benzaldehyde

100-52-7

aldehydes

+

0.03

Dimethyl succinate

106-65-0

esters

+

0.05

Dimethyl trisulfide

3658-80-8

sulfurs

+

0.04

Dimethylamine

124-40-3

amines

+++

0.1

exo-Brevicomin

20290-99-7

ethers

+

0.03

gamma-Crotonolactone

497-23-4

esters

+

0.05

gamma-Hexanolactone

695-06-7

esters

+

0.02

Maltol

118-71-8

pyrans

+

0.02

N,N-Dimethylacetamide

127-19-5

amines

+

0.08

N-Benzylidenemethylamine

622-29-7

amines

+++

0.06

Phenol

108-95-2

phenols

+

0.01

Phenylacetone

103-79-7

ketones

+

0.07

p-Toluidine

106-49-0

amines

+

0.03

Pyrazinamide

98-96-4

amides

+

0.01

Quinazoline

253-82-7

Quinazolines

+++

0.07

Trimethylamine

75-50-3

amines

+

0.02

Decreased compound

CAS No.

Classification

fold

p-value

4-Methyl-6-hepten-3-one

26118-97-8

ketones

--

< 0.01

  1. This table shows the VOCs, which were significantly different (p < 0.10) and more than 1.5 fold different to the averaged peak area (n = 3). The fold change indicates the difference in the averaged peak area between the tumor-bearing mice and normal control mice (+++ > 3 fold increase, ++ > 2 fold increase, + > 1.5 fold increase, --- < 3 fold decrease, -- < 2 fold decrease, - < 1.5 fold decrease).