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Figure 5 | Cancer Cell International

Figure 5

From: HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line

Figure 5

Evaluation of ATRA-differentiation in presence of the apoptotic inhibitor z-VAD. Surface markers analysis of CD11b (at day 6) and G-CSFR (after 1 hr) in LXSN- and HOXB1-transduced HL60 cells in low serum and ATRA (10-7 M), z-VAD (25 μM) and z-VAD (25 μM) + ATRA (10-7 M) treatments (a). Morphological analysis (b) and representative pictures (c). Cells were detected by the Giemsa-McGrünwald colorimetric method. Arrowheads indicate mature cells, long arrows blasts and double arrows intermediate cells.

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