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Table 1 Differentially expressed genes evaluated by macroarray in HL60/HOXB1 vs HL60/LXSN

From: HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line

Gene

GenBankID

Function

Ratio HOXB1/LXSN

qRT-PCR ratio

BRCA2

U43746

Oncogenes & tumor

0,10

 

CCNI

D50310

Cell cycle regulators

0,34

 

EGR1

X52541

Transcriptional regulators

0,21

0,02

FASN

S80437

Fatty acid/Lipid metabolism

0,13

0,25

FBP2

U69126

Hydrolases/carbohydrate biosynthesis

0,50

 

MDM2

Z12020

Oncogenes/Apoptosis assoc. proteins

0,31

0,5

OAS1

M11810

NucleotidylTransferases

0,06

 

SKY

D17517

Protein kinases receptors

0,58

 

SOD1

K000454

Antioxidant/Oxidoreductases

0,65

0,7

TNFRSF1A

L41690

Growth factor receptors

0,06

 

AKAP1

X97335

Mitochondrial targeting of proteins

1,94

 

CASP2

U13021

Cysteine proteases/Caspases

1,63

1,4

CCND3

M92287

Cell cycle regulators

4,54

 

CDC37

U63131

Cell cycle regulators

7,03

 

CRM1

Y08614

Transporter proteins

2,43

 

MAPRE1

U24166

Cytoskeleton Regulators

1,62

 

EIF3B

U78525

Initiation of translation factors

2,49

 

ERBB3

M29366

Receptor tyrosine kinases

3,00

 

JNK2

L31951

Intracellular kinase network members

1,93

 

KPNB1

L38951

Transporter proteins

1,59

 

NME1

X17620

Kinases/ Transferases

2,62

1,4

PDCD10

AF022385

Apoptosis-associated proteins

3,50

1,4

PTP4A1

U48296

Protein tyrosine phosphatases

2,00

 

RPS5

U14970

Ribosomal proteins

3,00

 

SPARC

J03040

Matrix-associated proteins

2,85

1,5

ST13

U28918

HSC70-interacting proteins

2,00

 

TRAM

X63679

Secreted protein translocation

2,55

 
  1. Differential gene expression was confirmed by RT-PCR when indicated. The reported ratio indicates the observed fold increase or decrease of the HL60/HOXB1 gene expression over HL60/LXSN. Cut-off value 1,6.