TY - JOUR AU - Maluccio, M. AU - Covey, A. PY - 2012 DA - 2012// TI - Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma JO - CA Cancer J Clin VL - 62 UR - https://doi.org/10.3322/caac.21161 DO - 10.3322/caac.21161 ID - Maluccio2012 ER - TY - JOUR AU - Subramaniam, A. AU - Shanmugam, M. K. AU - Perumal, E. AU - Li, F. AU - Nachiyappan, A. AU - Dai, X. AU - Swamy, S. N. AU - Ahn, K. S. AU - Kumar, A. P. AU - Tan, B. K. PY - 2013 DA - 2013// TI - Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma JO - Biochim Biophys Acta VL - 1835 ID - Subramaniam2013 ER - TY - JOUR AU - Damdinsuren, B. AU - Nagano, H. AU - Monden, M. PY - 2007 DA - 2007// TI - Combined intra-arterial 5-fluorouracil and subcutaneous interferon-alpha therapy for highly advanced hepatocellular carcinoma JO - Hepatol Res VL - 37 UR - https://doi.org/10.1111/j.1872-034X.2007.00191.x DO - 10.1111/j.1872-034X.2007.00191.x ID - Damdinsuren2007 ER - TY - JOUR AU - Patt, Y. Z. AU - Hassan, M. M. AU - Lozano, R. D. AU - Brown, T. D. AU - Vauthey, J. N. AU - Curley, S. A. AU - Ellis, L. M. PY - 2003 DA - 2003// TI - Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma JO - J Clin Oncol VL - 21 UR - https://doi.org/10.1200/JCO.2003.10.103 DO - 10.1200/JCO.2003.10.103 ID - Patt2003 ER - TY - JOUR AU - Sakabe, T. AU - Tsuchiya, H. AU - Kanki, K. AU - Azumi, J. AU - Gonda, K. AU - Mizuta, Y. AU - Yamada, D. AU - Wada, H. AU - Shomori, K. AU - Nagano, H. PY - 2013 DA - 2013// TI - Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-alpha/5-fluorouracil and their clinical significance JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0056197 DO - 10.1371/journal.pone.0056197 ID - Sakabe2013 ER - TY - CHAP AU - Tan, Y. AU - Qin, S. AU - Hou, X. AU - Qian, X. AU - Xia, J. AU - Li, Y. AU - Wang, R. AU - Chen, C. AU - Yang, Q. AU - Miele, L. PY - 2013 DA - 2013// TI - Proteomic-based analysis for identification of proteins involved in 5-fluorouracil resistance in hepatocellular carcinoma BT - Curr Pharm Des ID - Tan2013 ER - TY - JOUR AU - Zhou, S. AU - Ye, W. AU - Duan, X. AU - Zhang, M. AU - Wang, J. PY - 2013 DA - 2013// TI - The Noncytotoxic Dose of Sorafenib Sensitizes Bel-7402/5-FU Cells to 5-FU by Down-Regulating 5-FU-Induced Nrf2 Expression JO - Dig Dis Sci VL - 58 UR - https://doi.org/10.1007/s10620-012-2537-1 DO - 10.1007/s10620-012-2537-1 ID - Zhou2013 ER - TY - JOUR AU - Vollmer, J. AU - Krieg, A. M. PY - 2009 DA - 2009// TI - Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists JO - Adv Drug Deliv Rev VL - 61 UR - https://doi.org/10.1016/j.addr.2008.12.008 DO - 10.1016/j.addr.2008.12.008 ID - Vollmer2009 ER - TY - JOUR AU - Krieg, A. M. PY - 2006 DA - 2006// TI - Therapeutic potential of Toll-like receptor 9 activation JO - Nat Rev Drug Discov VL - 5 UR - https://doi.org/10.1038/nrd2059 DO - 10.1038/nrd2059 ID - Krieg2006 ER - TY - JOUR AU - Tanaka, J. AU - Sugimoto, K. AU - Shiraki, K. AU - Tameda, M. AU - Kusagawa, S. AU - Nojiri, K. AU - Beppu, T. AU - Yoneda, K. AU - Yamamoto, N. AU - Uchida, K. PY - 2010 DA - 2010// TI - Functional cell surface expression of toll-like receptor 9 promotes cell proliferation and survival in human hepatocellular carcinomas JO - Int J Oncol VL - 37 UR - https://doi.org/10.3892/ijo_00000753 DO - 10.3892/ijo_00000753 ID - Tanaka2010 ER - TY - JOUR AU - Krieg, A. M. PY - 2007 DA - 2007// TI - Development of TLR9 agonists for cancer therapy JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI31414 DO - 10.1172/JCI31414 ID - Krieg2007 ER - TY - JOUR AU - Mason, K. A. AU - Neal, R. AU - Hunter, N. AU - Ariga, H. AU - Ang, K. AU - Milas, L. PY - 2006 DA - 2006// TI - CpG oligodeoxynucleotides are potent enhancers of radio- and chemoresponses of murine tumors JO - Radiother Oncol VL - 80 UR - https://doi.org/10.1016/j.radonc.2006.07.024 DO - 10.1016/j.radonc.2006.07.024 ID - Mason2006 ER - TY - JOUR AU - Sommariva, M. AU - De Cecco, L. AU - De Cesare, M. AU - Sfondrini, L. AU - Menard, S. AU - Melani, C. AU - Delia, D. AU - Zaffaroni, N. AU - Pratesi, G. AU - Uva, V. PY - 2011 DA - 2011// TI - TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects JO - Cancer Res VL - 71 UR - https://doi.org/10.1158/0008-5472.CAN-11-1285 DO - 10.1158/0008-5472.CAN-11-1285 ID - Sommariva2011 ER - TY - JOUR AU - Manegold, C. AU - Gravenor, D. AU - Woytowitz, D. AU - Mezger, J. AU - Hirsh, V. AU - Albert, G. AU - Al-Adhami, M. AU - Readett, D. AU - Krieg, A. M. AU - Leichman, C. G. PY - 2008 DA - 2008// TI - Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer JO - J Clin Oncol VL - 26 UR - https://doi.org/10.1200/JCO.2007.12.5807 DO - 10.1200/JCO.2007.12.5807 ID - Manegold2008 ER - TY - JOUR AU - Krieg, A. M. PY - 2008 DA - 2008// TI - Toll-like receptor 9 (TLR9) agonists in the treatment of cancer JO - Oncogene VL - 27 UR - https://doi.org/10.1038/sj.onc.1210911 DO - 10.1038/sj.onc.1210911 ID - Krieg2008 ER - TY - JOUR AU - Kwon, S. AU - Kim, D. AU - Park, B. K. AU - Cho, S. AU - Kim, K. D. AU - Kim, Y. E. AU - Park, C. S. AU - Ahn, H. J. AU - Seo, J. N. AU - Choi, K. C. PY - 2012 DA - 2012// TI - Prevention and therapy of hepatocellular carcinoma by vaccination with TM4SF5 epitope-CpG-DNA-liposome complex without carriers JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0033121 DO - 10.1371/journal.pone.0033121 ID - Kwon2012 ER - TY - JOUR AU - Droemann, D. AU - Albrecht, D. AU - Gerdes, J. AU - Ulmer, A. J. AU - Branscheid, D. AU - Vollmer, E. AU - Dalhoff, K. AU - Zabel, P. AU - Goldmann, T. PY - 2005 DA - 2005// TI - Human lung cancer cells express functionally active Toll-like receptor 9 JO - Respir Res VL - 6 UR - https://doi.org/10.1186/1465-9921-6-1 DO - 10.1186/1465-9921-6-1 ID - Droemann2005 ER - TY - JOUR AU - Michaud, W. A. AU - Nichols, A. C. AU - Mroz, E. A. AU - Faquin, W. C. AU - Clark, J. R. AU - Begum, S. AU - Westra, W. H. AU - Wada, H. AU - Busse, P. M. AU - Ellisen, L. W. PY - 2009 DA - 2009// TI - Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-08-2581 DO - 10.1158/1078-0432.CCR-08-2581 ID - Michaud2009 ER - TY - JOUR AU - Bowen, A. R. AU - Hanks, A. N. AU - Allen, S. M. AU - Alexander, A. AU - Diedrich, M. J. AU - Grossman, D. PY - 2003 DA - 2003// TI - Apoptosis regulators and responses in human melanocytic and keratinocytic cells JO - J Invest Dermatol VL - 120 UR - https://doi.org/10.1046/j.1523-1747.2003.12010.x DO - 10.1046/j.1523-1747.2003.12010.x ID - Bowen2003 ER - TY - JOUR AU - Augello, C. AU - Caruso, L. AU - Maggioni, M. AU - Donadon, M. AU - Montorsi, M. AU - Santambrogio, R. AU - Torzilli, G. AU - Vaira, V. AU - Pellegrini, C. AU - Roncalli, M. PY - 2009 DA - 2009// TI - Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma JO - Bmc Cancer VL - 9 UR - https://doi.org/10.1186/1471-2407-9-125 DO - 10.1186/1471-2407-9-125 ID - Augello2009 ER - TY - JOUR AU - Wang, H. AU - Rayburn, E. R. AU - Wang, W. AU - Kandimalla, E. R. AU - Agrawal, S. AU - Zhang, R. PY - 2006 DA - 2006// TI - Chemotherapy and chemosensitization of non-small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9 JO - Mol Cancer Ther VL - 5 UR - https://doi.org/10.1158/1535-7163.MCT-06-0094 DO - 10.1158/1535-7163.MCT-06-0094 ID - Wang2006 ER - TY - JOUR AU - Rayburn, E. R. AU - Wang, W. AU - Zhang, Z. AU - Li, M. AU - Zhang, R. AU - Wang, H. PY - 2006 DA - 2006// TI - Experimental therapy of prostate cancer with an immunomodulatory oligonucleotide: effects on tumor growth, apoptosis, proliferation, and potentiation of chemotherapy JO - Prostate VL - 66 UR - https://doi.org/10.1002/pros.20485 DO - 10.1002/pros.20485 ID - Rayburn2006 ER - TY - JOUR AU - Krieg, A. M. PY - 2012 DA - 2012// TI - CpG still rocks! Update on an accidental drug JO - Nucleic Acid Ther VL - 22 ID - Krieg2012 ER - TY - JOUR AU - Shirota, Y. AU - Shirota, H. AU - Klinman, D. M. PY - 2012 DA - 2012// TI - Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells JO - J Immunol VL - 188 UR - https://doi.org/10.4049/jimmunol.1101304 DO - 10.4049/jimmunol.1101304 ID - Shirota2012 ER - TY - JOUR AU - De Cecco, L. AU - Berardi, M. AU - Sommariva, M. AU - Cataldo, A. AU - Canevari, S. AU - Mezzanzanica, D. AU - Iorio, M. V. AU - Tagliabue, E. AU - Balsari, A. PY - 2013 DA - 2013// TI - Increased Sensitivity to Chemotherapy Induced by CpG-ODN Treatment Is Mediated by microRNA Modulation JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0058849 DO - 10.1371/journal.pone.0058849 ID - De Cecco2013 ER - TY - JOUR AU - Wang, X. S. AU - Sheng, Z. AU - Ruan, Y. B. AU - Guang, Y. AU - Yang, M. L. PY - 2005 DA - 2005// TI - CpG oligodeoxynucleotides inhibit tumor growth and reverse the immunosuppression caused by the therapy with 5-fluorouracil in murine hepatoma JO - World J Gastroenterol VL - 11 UR - https://doi.org/10.3748/wjg.v11.i8.1220 DO - 10.3748/wjg.v11.i8.1220 ID - Wang2005 ER - TY - JOUR AU - El, A. A. AU - Sonabend, A. M. AU - Han, Y. AU - Lesniak, M. S. PY - 2006 DA - 2006// TI - Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors JO - Glia VL - 54 UR - https://doi.org/10.1002/glia.20401 DO - 10.1002/glia.20401 ID - El2006 ER - TY - JOUR AU - Qi, X. F. AU - Zheng, L. AU - Kim, C. S. AU - Lee, K. J. AU - Kim, D. H. AU - Cai, D. Q. AU - Qin, J. W. AU - Yu, Y. H. AU - Wu, Z. AU - Kim, S. K. PY - 2013 DA - 2013// TI - CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways JO - Mol Immunol VL - 54 UR - https://doi.org/10.1016/j.molimm.2013.01.001 DO - 10.1016/j.molimm.2013.01.001 ID - Qi2013 ER - TY - JOUR AU - Heckelsmiller, K. AU - Beck, S. AU - Rall, K. AU - Sipos, B. AU - Schlamp, A. AU - Tuma, E. AU - Rothenfusser, S. AU - Endres, S. AU - Hartmann, G. PY - 2002 DA - 2002// TI - Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy JO - Eur J Immunol VL - 32 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - Heckelsmiller2002 ER - TY - JOUR AU - Bourquin, C. AU - Schreiber, S. AU - Beck, S. AU - Hartmann, G. AU - Endres, S. PY - 2006 DA - 2006// TI - Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer JO - Int J Cancer VL - 118 UR - https://doi.org/10.1002/ijc.21681 DO - 10.1002/ijc.21681 ID - Bourquin2006 ER - TY - JOUR AU - Wang, H. AU - Rayburn, E. R. AU - Wang, W. AU - Kandimalla, E. R. AU - Agrawal, S. AU - Zhang, R. PY - 2006 DA - 2006// TI - Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy JO - Mol Cancer Ther VL - 5 UR - https://doi.org/10.1158/1535-7163.MCT-06-0158 DO - 10.1158/1535-7163.MCT-06-0158 ID - Wang2006 ER - TY - JOUR AU - Rayburn, E. R. AU - Wang, W. AU - Zhang, R. AU - Wang, H. PY - 2007 DA - 2007// TI - Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53 JO - Int J Oncol VL - 30 ID - Rayburn2007 ER - TY - JOUR AU - Fei, H. R. AU - Chen, G. AU - Wang, J. M. AU - Wang, F. Z. PY - 2010 DA - 2010// TI - Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation JO - Cytotechnology VL - 62 UR - https://doi.org/10.1007/s10616-010-9299-4 DO - 10.1007/s10616-010-9299-4 ID - Fei2010 ER - TY - JOUR AU - Zhang, L. AU - Jiang, G. AU - Yao, F. AU - He, Y. AU - Liang, G. AU - Zhang, Y. AU - Hu, B. AU - Wu, Y. AU - Li, Y. AU - Liu, H. PY - 2012 DA - 2012// TI - Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0037865 DO - 10.1371/journal.pone.0037865 ID - Zhang2012 ER - TY - JOUR AU - Chung, H. AU - Chaudhry, J. AU - Lopez, C. G. AU - Carethers, J. M. PY - 2010 DA - 2010// TI - Cyclin E and histone H3 levels are regulated by 5-fluorouracil in a DNA mismatch repair-dependent manner JO - Cancer Biol Ther VL - 10 UR - https://doi.org/10.4161/cbt.10.11.13447 DO - 10.4161/cbt.10.11.13447 ID - Chung2010 ER - TY - JOUR AU - Gapany, C. AU - Zhao, M. AU - Zimmermann, A. PY - 1997 DA - 1997// TI - The apoptosis protector, bcl-2 protein, is downregulated in bile duct epithelial cells of human liver allografts JO - J Hepatol VL - 26 UR - https://doi.org/10.1016/S0168-8278(97)80418-7 DO - 10.1016/S0168-8278(97)80418-7 ID - Gapany1997 ER - TY - JOUR AU - Losert, D. AU - Pratscher, B. AU - Soutschek, J. AU - Geick, A. AU - Vornlocher, H. P. AU - Muller, M. AU - Wacheck, V. PY - 2007 DA - 2007// TI - Bcl-2 downregulation sensitizes nonsmall cell lung cancer cells to cisplatin, but not to docetaxel JO - Anticancer Drugs VL - 18 UR - https://doi.org/10.1097/CAD.0b013e3280adc8c8 DO - 10.1097/CAD.0b013e3280adc8c8 ID - Losert2007 ER - TY - JOUR AU - Sun, J. G. AU - Liao, R. X. AU - Zhang, S. X. AU - Duan, Y. Z. AU - Zhuo, W. L. AU - Wang, X. X. AU - Wang, Z. X. AU - Li, D. Z. AU - Chen, Z. T. PY - 2011 DA - 2011// TI - Role of inhibitor of apoptosis protein Livin in radiation resistance in nonsmall cell lung cancer JO - Cancer Biother Radiopharm VL - 26 UR - https://doi.org/10.1089/cbr.2011.0962 DO - 10.1089/cbr.2011.0962 ID - Sun2011 ER - TY - JOUR AU - Wang, X. AU - Xu, J. AU - Ju, S. AU - Ni, H. AU - Zhu, J. AU - Wang, H. PY - 2010 DA - 2010// TI - Livin gene plays a role in drug resistance of colon cancer cells JO - Clin Biochem VL - 43 UR - https://doi.org/10.1016/j.clinbiochem.2010.02.004 DO - 10.1016/j.clinbiochem.2010.02.004 ID - Wang2010 ER - TY - JOUR AU - Chen, Y. S. AU - Li, H. R. AU - Lin, M. AU - Chen, G. AU - Xie, B. S. AU - Xu, N. L. AU - Lin, L. F. PY - 2010 DA - 2010// TI - Livin abrogates apoptosis of SPC-A1 cell by regulating JNKI signaling pathway JO - Mol Biol Rep VL - 37 UR - https://doi.org/10.1007/s11033-009-9711-3 DO - 10.1007/s11033-009-9711-3 ID - Chen2010 ER - TY - JOUR AU - Chu, J. AU - Wu, S. AU - Xing, D. PY - 2010 DA - 2010// TI - Survivin mediates self-protection through ROS/cdc25c/CDK1 signaling pathway during tumor cell apoptosis induced by high fluence low-power laser irradiation JO - Cancer Lett VL - 297 UR - https://doi.org/10.1016/j.canlet.2010.05.013 DO - 10.1016/j.canlet.2010.05.013 ID - Chu2010 ER - TY - JOUR AU - Wenying, Z. AU - Zhaoning, J. AU - Zhimin, Y. AU - Dongyun, C. AU - Lili, S. PY - 2012 DA - 2012// TI - Survivin siRNA inhibits gastric cancer in nude mice JO - Cell Biochem Biophys VL - 62 UR - https://doi.org/10.1007/s12013-011-9315-0 DO - 10.1007/s12013-011-9315-0 ID - Wenying2012 ER - TY - JOUR AU - Dasgupta, A. AU - Alvarado, C. S. AU - Xu, Z. AU - Findley, H. W. PY - 2010 DA - 2010// TI - Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma JO - Biochem Biophys Res Commun VL - 400 UR - https://doi.org/10.1016/j.bbrc.2010.08.001 DO - 10.1016/j.bbrc.2010.08.001 ID - Dasgupta2010 ER - TY - JOUR AU - Chandele, A. AU - Prasad, V. AU - Jagtap, J. C. AU - Shukla, R. AU - Shastry, P. R. PY - 2004 DA - 2004// TI - Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis JO - Neoplasia VL - 6 UR - https://doi.org/10.1016/S1476-5586(04)80051-4 DO - 10.1016/S1476-5586(04)80051-4 ID - Chandele2004 ER -