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Figure 1 | Cancer Cell International

Figure 1

From: CpG oligodeoxynucleotides enhance chemosensitivity of 5-fluorouracil in HepG2 human hepatoma cells via downregulation of the antiapoptotic factors survivin and livin

Figure 1

Effect of CpG-ODN and/or 5-FU treatment on the cell viability in vitro. A: The cell viability of HepG2 cells, BEL-7402 cells and A549 cells treated with indicated concentration of CpG-ODN for 48 h in MTS assay, cell viability was expressed as the percentage of control cells (medium). B: The cell viability of HepG2 cells treated with indicated concentration of CpG-ODN for indicated time in MTS assay, cell viability was then quantified as described above. C: The cell viability of HepG2 cells treated with indicated concentration of non-CpG-ODN and ODN M362 for 48 h in MTS assay, cell viability was then quantified as described above. D: HepG2 cells were treated with indicated concentration of 5-FU for indicated time in MTS assay, results were presented as the inhibitory ratio of 5-FU treated HepG2 cells. E: HepG2 cells treated with indicated concentration of CpG-ODN, 5-FU or CpG-ODN in combination with 5-FU for indicated time, inhibition was then determined by the MTS assay. F: The inhibitory ratio of HepG2 cells treated with a rang of 5-FU doses in the presence and absence of 4μM CpG-ODN or non-CpG-ODN for 24h. In this figure, 5-FU, CpG(2) ,CpG(4) and non-CpG(4) represent that the concentration of 5-FU,CpG-ODN , CpG-ODN and non-CpG-ODN is 7.5 μg/ml , 2 μM ,4 μM, 4 μM, respectively. All results shown were means ±SD from three independent experiments. *P<0.05, **P<0.01 and ***P<0.001 versus medium.

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