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Table 4 The relationships between FPGS rs1544105 genotypes and MTX-related toxicity (SR and MR, N = 139)

From: FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Toxicity FPGS SNP rs1544105 p-value*
CC (n,%) CT + TT (n,%)
Oral mucositis    
With 1 (8.3) 11 (8.7) 0.969
Without 11 (91.7) 116 (91.3)  
Skin toxicity    
With 1 (8.3) 10 (7.9) 0.955
Without 11 (91.7) 117 (92.1)  
Hepatic toxicity    
With 0 (0) 17 (13.4) 0.176
Without 12 (100.0) 110 (86.6)  
Anemia    
With 6 (50.0) 52 (40.9) 0.543
Without 6 (50.0) 75 (59.1)  
Neutropenia    
With 6 (50.0) 77 (60.6) 0.473
Without 6 (50.0) 50 (39.4)  
Thrombocytopenia    
With 2(16.7) 25 (19.7) 0.801
Without 10 (83.3) 102 (80.3)  
  1. *Data were calculated by χ2 test.
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