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Table 4 The relationships between FPGS rs1544105 genotypes and MTX-related toxicity (SR and MR, N = 139)

From: FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Toxicity

FPGS SNP rs1544105

p-value*

CC (n,%)

CT + TT (n,%)

Oral mucositis

   

With

1 (8.3)

11 (8.7)

0.969

Without

11 (91.7)

116 (91.3)

 

Skin toxicity

   

With

1 (8.3)

10 (7.9)

0.955

Without

11 (91.7)

117 (92.1)

 

Hepatic toxicity

   

With

0 (0)

17 (13.4)

0.176

Without

12 (100.0)

110 (86.6)

 

Anemia

   

With

6 (50.0)

52 (40.9)

0.543

Without

6 (50.0)

75 (59.1)

 

Neutropenia

   

With

6 (50.0)

77 (60.6)

0.473

Without

6 (50.0)

50 (39.4)

 

Thrombocytopenia

   

With

2(16.7)

25 (19.7)

0.801

Without

10 (83.3)

102 (80.3)

 
  1. *Data were calculated by χ2 test.
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Cancer Cell International

ISSN: 1475-2867

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