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Figure 8 | Cancer Cell International

Figure 8

From: Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines

Figure 8

Oncogenic signal transduction downregulation (II). Left panel: Western blotting experiments presenting protein expression levels of total and constitutively phosphorylated FOXO transcription factors and p44/42 MAP kinases, in RT4 and T24 bladder cancer cells, upon geldanamycin administration for 24 hours. Right panel: protein densitometric quantification bars, denoting the drug-induced expression level alterations of the FOXO and MAPK family members examined, and their respective phosphorylated forms, compared to control conditions, using Actin (left panel) as protein of reference. All experiments were repeated three times, with a typically obtained image collection shown here. Standard deviation values are depicted as error bars on top of each value.

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Cancer Cell International

ISSN: 1475-2867

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