CD44 suppression inhibited nuclear translocation of β-catenin. (A) Decreased β-catenin mRNA expression after CD44shRNA transfection. (B) The protein expressions of β-catenin and p-β-catenin. (C/D) The relative protein expression of β-catenin and p-β-catenin compared to GAPDH. *, P < 0.05, **, P < 0.01, compared with the control. (E) Confocal laser microscope showing the decreased nuclear translocation of β-catenin after treatment with CD44shRNA. The green panel is GFP; the red panel isβ-catenin and the blue panel is cell nuclear.