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Table 2 Characteristics of the MMLAL versus other Chinese-derived (MM17 and CZ-1) and several commonly used human myeloma cell lines

From: Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL

Cell line MMLAL MM17 KMS-12-PE NCI-H929 U-266 LP-1 OPM-2 MOLP-8 CZ-1 RPMI8226
Site of origin Pleural effusion Sacral plasmacytoma Pleural effusion Pleural effusion Peripheral blood Peripheral blood Peripheral blood Peripheral blood Bone marrow or peripheral blood Peripheral blood
Gender XY XX XX XX XY XX XX XY XY XY
Ig type IgG lambda IgG kappa Ig-non-producing IgA kappa IgE lambda IgG lambda IgG lambda IgD lambda Light chain lambda IgG lambda
Ploidy Hypodiploid Hypodiploid Hypodiploid Hypodiploid Hypodiploid Near-tetraploid Near-tetraploid Near-diploid Hyperdiploid Hyperdiploid
Known IgH translocation Nil t(8;14)(q24;q32) t(11;14)(q13;q32) t(4;14)(p16.3;q32.3) Nil t(4;14)(p16.3;q32.3) t(4;14)(p16.3;q32.3) t(11;14)(q13;q32) Nil t(1;14)(p13;q32)
Chromosome 13 status -13 -13 del(13)(q11) -13 -13 -13 Nil Nil Nil -13
TP53 status -17; wild-type Homozygous deletion Wild-type Not known Mutated Mutated Mutated Not known i(17q) Mutated
Reference [11, 12]