Table 2 Characteristics of the MMLAL versus other Chinese-derived (MM17 and CZ-1) and several commonly used human myeloma cell lines
From: Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL
Cell line | MMLAL | MM17 | KMS-12-PE | NCI-H929 | U-266 | LP-1 | OPM-2 | MOLP-8 | CZ-1 | RPMI8226 |
|---|---|---|---|---|---|---|---|---|---|---|
Site of origin | Pleural effusion | Sacral plasmacytoma | Pleural effusion | Pleural effusion | Peripheral blood | Peripheral blood | Peripheral blood | Peripheral blood | Bone marrow or peripheral blood | Peripheral blood |
Gender | XY | XX | XX | XX | XY | XX | XX | XY | XY | XY |
Ig type | IgG lambda | IgG kappa | Ig-non-producing | IgA kappa | IgE lambda | IgG lambda | IgG lambda | IgD lambda | Light chain lambda | IgG lambda |
Ploidy | Hypodiploid | Hypodiploid | Hypodiploid | Hypodiploid | Hypodiploid | Near-tetraploid | Near-tetraploid | Near-diploid | Hyperdiploid | Hyperdiploid |
Known IgH translocation | Nil | t(8;14)(q24;q32) | t(11;14)(q13;q32) | t(4;14)(p16.3;q32.3) | Nil | t(4;14)(p16.3;q32.3) | t(4;14)(p16.3;q32.3) | t(11;14)(q13;q32) | Nil | t(1;14)(p13;q32) |
Chromosome 13 status | -13 | -13 | del(13)(q11) | -13 | -13 | -13 | Nil | Nil | Nil | -13 |
TP53 status | -17; wild-type | Homozygous deletion | Wild-type | Not known | Mutated | Mutated | Mutated | Not known | i(17q) | Mutated |
Reference | ||||||||||