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Figure 1 | Cancer Cell International

Figure 1

From: Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer

Figure 1

The crosstalk between integrin beta1 and c-MET. A Western blot analysis showed that integrin beta1 and c-Met co-expressed in PC9 and PC9/AB2 cells. B MTT analysis of proliferative effect of PC9 and PC9/AB2 cells treated with FN and HGF alone or in combination showed a synergistic proliferative effect when FN and HGF combined. C MTT analysis showed that combination of integrin beta1-target siRNA and c-MET kinase inhibitor SU11274 synergized to inhibit proliferation of PC9/AB2 NSCLC cell line. D TUNEL analysis showed that inhibition of c-Met and integrin beta1 concurrently induced apoptosis synergistically. E Western blot analysis showed that phosphorylation of c-Met, EGFR, FAK and AKT were reduced synergistically when c-Met and integrin beta1 were inhibited in PC9/AB2 cells. *G means treatment of gefitinib and P means phosphorylation.

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