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Figure 1 | Cancer Cell International

Figure 1

From: Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells

Figure 1

Effects of HDAC inhibitors on BCR-ABL-expressing cells. (A) K562 and mutant Ba/F3 cells (T315I) were treated with vorinostat or pracinostat for 72 h. The number of viable cells was calculated for each group. *P < 0.05, vorinostat or pracinostat treatment versus control in the same cell line. (B) K562 cells were treated with vorinostat or pracinostat at the indicated concentrations for 48 h. Total extracts were analyzed by immunoblotting with anti-Aurora A and B Abs. Actin was used as the loading control. Band intensities were quantified using ImageJ software. Results in A and B are representative of at least 3 reproducible experiments.

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Cancer Cell International

ISSN: 1475-2867

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